Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/35161
標題: Synthesis of Aryl Thioethers Through the NCS-Promoted Cross-Coupling Reaction of Thiols with Grignard Reagents
作者: Cheng, Jun-Hao
Ramesh, Chintakunta
Kao, Hsin-Lun
Wang, Yu-Jen
Chan, Chien-Ching
Lee, Chin-Fa
摘要: A convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were formed when thiols were treated with N-chlorosuccinimide, and the resulting sulfenylchlorides were then directly reacted with Grignard reagents to provide aryl sulfides in good to excellent yields under mild reaction conditions. Functional groups including ester, fluoro and chloro are tolerated by the reaction conditions employed. It is important to note that this method has a short reaction time (30 min in total), and represents an alternative approach for the synthesis of aryl sulfides over the existing protocols.
URI: http://hdl.handle.net/11455/35161
文章連結: http://dx.doi.org/10.1021/jo302088t
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