Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/35161
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dc.contributor.authorCheng, Jun-Haoen_US
dc.contributor.authorRamesh, Chintakuntaen_US
dc.contributor.authorKao, Hsin-Lunen_US
dc.contributor.authorWang, Yu-Jenen_US
dc.contributor.authorChan, Chien-Chingen_US
dc.contributor.authorLee, Chin-Faen_US
dc.date2012-12zh_TW
dc.date.accessioned2014-06-06T07:48:52Z-
dc.date.available2014-06-06T07:48:52Z-
dc.identifier.urihttp://hdl.handle.net/11455/35161-
dc.description.abstractA convenient one-pot approach for the synthesis of aryl sulfides through the coupling of thiols with Grignard reagents in the presence of N-chlorosuccinimide is described. The sulfenylchlorides were formed when thiols were treated with N-chlorosuccinimide, and the resulting sulfenylchlorides were then directly reacted with Grignard reagents to provide aryl sulfides in good to excellent yields under mild reaction conditions. Functional groups including ester, fluoro and chloro are tolerated by the reaction conditions employed. It is important to note that this method has a short reaction time (30 min in total), and represents an alternative approach for the synthesis of aryl sulfides over the existing protocols.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Organic Chemistry, Volume 77, Issue 22, page(s) 10369–10374.en_US
dc.relation.urihttp://dx.doi.org/10.1021/jo302088ten_US
dc.titleSynthesis of Aryl Thioethers Through the NCS-Promoted Cross-Coupling Reaction of Thiols with Grignard Reagentsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/jo302088tzh_TW
dc.contributor.catalogerWei Chun Wangen_US
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