Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/37027
標題: Prenatal smoking exposure and neonatal DNA damage in relation to birth outcomes
作者: Tsui, H.C.
吳宏達
Wu, H.D.I.
Lin, C.J.
Wang, R.Y.
Chiu, H.T.
Cheng, Y.C.
Chiu, T.H.
Wu, F.Y.
關鍵字: environmental tobacco-smoke
comet assay
passive smoking
gestational-age
pregnant-women
serum cotinine
blood-cells
weight
infant
susceptibility
期刊/報告no:: Pediatric Research, Volume 64, Issue 2, Page(s) 131-134.
摘要: This study investigated whether mothers with prenatal environmental tobacco smoke (ETS) exposure increased the newborn genetic damage and adverse birth outcomes. Study participants were women receiving prenatal care at three hospitals in Central Taiwan and their newborns. Participants were divided into two groups (nonsmokers and ETS-exposed non-smokers) based on maternal ETS-exposed status. Comet assay were performed for cord blood samples. Infants born to mothers with prenatal ETS exposure had the highest mean cord blood DNA damage score (69.7 +/- 42.3) and poorer birth outcomes. No negative fetal growth effects appeared among new-borns with low DNA damage levels. Among newborns with high DNA damage levels (comet scores > 50), those born to prenatal ETS exposure had an average reduction of 252.7 g in birth weight, 1.10 cm shorter in length and a 0.92-cm decrease in head circumference, compared to newborns with no smoking exposure. This study shows that the DNA damage scores can be used as an effect-modifier on the relationships between ETS exposure and adverse birth outcome. The association appears more apparent for the ETS exposure in relation with more severe DNA damage.
URI: http://hdl.handle.net/11455/37027
ISSN: 0031-3998
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