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dc.contributor.authorShen, Ching-Ien_US
dc.contributor.authorWang, Ching-Hoen_US
dc.contributor.authorShen, Shih-Chengen_US
dc.contributor.authorLee, Hsiu-Chinen_US
dc.contributor.authorLiao, Jiunn-Wangen_US
dc.contributor.authorSu, Hong-Linen_US
dc.contributor.otherNational Chung Hsing University,Department of Life Sciencesen_US
dc.description.abstractSialic acids (SAs) linked to galactose (Gal) in alpha 2,3- and alpha 2,6-configurations are the receptors for avian and human influenza viruses, respectively. We demonstrate that chicken tracheal ciliated cells express alpha 2,3-linked SA, while goblet cells mainly express alpha 2,6-linked SA. In addition, the plant lectin MAL-II, but not MAA/MAL-I, is bound to the surface of goblet cells, suggesting that SA2,3-linked oligosaccharides with Gal beta 1-3GalNAc subterminal residues are specifically present on the goblet cells. Moreover, both alpha 2,3- and alpha 2,6-linked SAs are detected on single tracheal basal cells. At a low multiplicity of infection (MOI) avian influenza virus H6N1 is exclusively detected in the ciliated cells, suggesting that the ciliated cell is the major target cell of the H6N1 virus. At a MOI of 1, ciliated, goblet and basal cells are all permissive to the AIV infection. This result clearly elucidates the receptor distribution for the avian influenza virus among chicken tracheal epithelial cells and illustrates a primary cell model for evaluating the cell tropisms of respiratory viruses in poultry.en_US
dc.relationPlos One, Volume 6, Issue 5, Page(s) e18894.en_US
dc.subjecttracheal epithelial cellen_US
dc.subjectinfluenza virusen_US
dc.subjectsialic aciden_US
dc.subjectviral receptoren_US
dc.titleThe Infection of Chicken Tracheal Epithelial Cells with a H6N1 Avian Influenza Virusen_US
dc.typeJournal Articlezh_TW
dc.contributor.catalogerMiao-zhen Luoen_US
Appears in Collections:生命科學系所


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