Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/37711
標題: MPTP Lesion Causes Neuroinflammation and Deficits in Object Recognition in Wistar Rats
作者: Wang, W.F.
劉英明
Wu, S.L.
Liou, Y.M.
Wang, A.L.
Pawlak, C.R.
Ho, Y.J.
關鍵字: cytokines
dementia
object recognition
neuroinflammation
microglial
activation
early parkinsons-disease
tumor-necrosis-factor
working-memory failure
nigra pars compacta
growth-factor-alpha
plus-maze behavior
microglial
activation
substantia-nigra
d-cycloserine
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mptp
期刊/報告no:: Behavioral Neuroscience, Volume 123, Issue 6, Page(s) 1261-1270.
摘要: Animal model of Parkinson's disease with dementia would greatly facilitate research into the underlying causes of this disorder. Here. we showed that bilateral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the substantia nigra pars compacta (SNc) of Wistar rats caused degeneration of nigrostriatal dopaminergic neurons. cell loss in the hippocampal CAI area, as well as microglial activation and increase of interleukin-2 levels in several brain regions In addition, increase of anxiety-like behavior and impairment of object recognition were observed in the MPTP-lesioned rats These findings suggest that neuroinflammation may contribute to MPTP-induced neurodegeneration and behavioral deficits, which is suggested as in animal model of Parkinson's disease dementia
URI: http://hdl.handle.net/11455/37711
ISSN: 0735-7044
文章連結: http://dx.doi.org/10.1037/a0017401
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