Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3817
標題: 兼具生物分解及生物相容性之聚乳酸-水性聚胺酯的合成
Synthesis of PLA-Waterborne Polyurethane (PU) Possessing Both Bio-degradable and Bio-compatible Characteristics
作者: 陳佑星
Chen, You-Sing
關鍵字: waterborne PU
水性聚胺酯
poly(L-lactide) diol
biodegradable polymer
biocompatible polymer
PLA-WBPU
聚乳酸二元醇
生物降解性
生物相容性
出版社: 化學工程學系所
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摘要: 本研究主要探討如何透過化學合成方式,結合生質塑膠-聚乳酸(PLA)以及水性聚胺酯(WBPU)兩種綠色材料,製作出具有生物可降解性及生物相容性之特殊產物,可望在生醫材料上發揮功用。首先將聚乳酸的末端官能基皆改質為醇基(-OH)結構的中間體,實際上是以1,4-丁二醇(1,4-Butanediol)作為起始劑與L型乳酸交酯(L-Lactide)單體經過開環聚合(Ring-opening polymerization)後,獲得分子量約為2,100 g/mol之L型聚乳酸二元醇(PLLA diol)。 接著以預聚物法合成含有聚乳酸鏈段之水性聚胺酯(PLLA-WBPU),合成配方當中只改變軟鏈段之組成,設計PLLA diol含量為0、20、40、60、80、100 wt%,剩餘之軟鏈段皆由另一聚酯型二元醇(RS-956)取代,而其他之配方材料選用IPDI (Isophorone diisocyanate)、DMPA(Dimethylolpropionic acid)、TEA(Triethylamine)、EDA (Ethylene diamine)作為合成水性聚胺酯之單體,合成結果利用儀器與分析方法瞭解,此含有聚乳酸鏈段之水性聚胺酯的熱性質、機械性質、分子量、水解速度,並試驗其生物相容性之特性。 實驗結果顯示,軟鏈段當中聚乳酸含量在40~60 wt%時,為較佳的配方組成,具有良好的機械性質(24~34 MPa)以及伸長率(217~274 %),不會因含有聚乳酸而呈現過度剛硬而易脆的性質,且在水解測試當中,不會因為長時間浸泡後而再次乳化成乳液。最後經測試結果此材料具有良好之生物相容性,因此極有希望運用於特殊以及高單價之生醫材料當中。
In this study, we have combined the chemical processing of waterborne polymers and bio-mass intermediates in our design of new green materials. In our synthesis of waterborne polyurethane (WBPU) with PLA segments, PLA-diol of 2,100 molecular weight was synthesized from butanediol and dilactide through ring-opening trans-esterification, and was used as the key raw materials for modifying soft-segment portion of WBPUs. In the hydrolysis test, degradability of WBPUs is dependent on the PLA wt% content in the WBPU where higher rates of water hydrolysis are correlated with the higher PLA-diol concentration. Our screening of WBPUs indicated that the use of PLA-diol contents at 40~60% in the soft segment has resulted in the PU films with optimal mechanical performances. In addition, cell toxicity analysis showed that the PLA-WBPU (P-40J9) films exhibit no detectable toxicity to fibroblast cells (L929 Test) and macrophages (J774A1 Test). This green material shows a great potential for use in the special medical applications.
URI: http://hdl.handle.net/11455/3817
其他識別: U0005-1808201013002700
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1808201013002700
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