Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38199
標題: Lactoferrin: an iron-binding antimicrobial protein against Escherichia coli infection
作者: Yen, C.C.
陳全木
Shen, C.J.
Hsu, W.H.
Chang, Y.H.
Lin, H.T.
Chen, H.L.
Chen, C.M.
關鍵字: Lactoferrin
E. coli infection
Host defense protein
Sepsis
Antimicrobial activity
Nosocomial infection
selective digestive decontamination
free secretory component
nf-kappa-b
bovine lactoferrin
capsule polysaccharide
antibacterial
activity
staphylococcus-aureus
candida-albicans
human-milk
mice
期刊/報告no:: Biometals, Volume 24, Issue 4, Page(s) 585-594.
摘要: Escherichia coli (E. coli) are the most common aerobic gram-negative bacilli in a normal intestinal tract. They cause most of the intra-abdominal infections, wound infections associated with abdominal surgery, and septicemia. Most of these infections are of endogenous intestinal origin. Lactoferrin (LF) is an iron-binding glycoprotein found in milk and various external secretions. This protein has been found to have a number of biological functions, including antimicrobial, anti-cancer, antioxidant, and immunomodulatory effects. Partial degradation of LF by pepsin can give rise to peptides termed lactoferricin (LFcin) with more potent antimicrobial activity. LF and LFcin have been shown to inhibit the growth of a number of pathogenic bacteria (including E. coli and antibiotic-resistant strains), fungi, and even viruses in both in vitro and in vivo studies. We previously demonstrated that both recombinant porcine LF (pLF) produced from yeast and a synthetic 20-residue porcine LFcin peptide exhibit antimicrobial activity in vitro. In one of our recent studies, we performed pathogen challenges, including pathogenic E. coli, Staphylococcus aureus and Candida albicans, of the digestive tract of a transgenic milk-fed animal model. The results showed that LF has broad spectrum antimicrobial activity in the digestive tract and protects the mucosa of the small intestine from injury. Our following study also revealed that pLF as a feedstuff additive enhances avian immunity, including antibody formation and cell-mediated immunity. All of these results suggest that LF could be a novel natural protein in the treatment and prevention of infections with E. coli or antibiotic-resistant bacteria strains.
URI: http://hdl.handle.net/11455/38199
ISSN: 0966-0844
文章連結: http://dx.doi.org/10.1007/s10534-011-9423-8
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