請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/38269
標題: Elevated plasma osteopontin level is associated with occurrence of psoriasis and is an unfavorable cardiovascular risk factor in patients with psoriasis
作者: 陳全木
Chen, Y.J.
Shen, J.L.
Wu, C.Y.
Chang, Y.T.
Chen, C.M.
Lee, F.Y.
關鍵字: necrosis-factor-alpha
human atherosclerotic plaques
systemic-lupus-erythematosus
intima-media thickness
metabolic
syndrome
skin inflammation
expression
gene
polymorphisms
macrophages
期刊/報告no:: Journal of the American Academy of Dermatology, Volume 60, Issue 2, Page(s) 225-230.
摘要: Background: The association between psoriasis and cardiovascular diseases is well documented yet the underlying mechanisms remain elusive. Objectives: We sought to study the role of circulating osteopontin (OPN) in the pathogenesis of cardiovascular diseases in patients with psoriasis. Methods: Plasma samples from 40 patients with psoriasis and 37 control subjects were collected for enzyme-linked immunosorbent assays. The clinical significance of OPN levels in patients with psoriasis versus control subjects was analyzed Using the Mann-Whitney U test and logistic regression. DNA samples from 268 patients with psoriasis and 146 control subjects were collected for genotyping of the OPN gene. Results: Higher body mass index values (P = .047) and hypertension (odds ratio [OR] 2.68, P = .05) were observed in patients with psoriasis. increased plasma OPN levels (>= 62-95 ng/mL) were significantly associated with psoriasis (OR 6.24, P = .001), hypertension (OR 3.05, P = .03), and diabetes mellitus (OR 333, P = .05). Occurrence of psoriasis (OR 5.12, P = .003) appeared to be the single independent risk factor for high plasma OPN values after multivariate logistic regression. Among patients with psoriasis, increased plasma OPN values were associated with the presence of hypertension (OR 4.69, P = .05). However, no significantly different allelic distributions of single nucleotide polymorphisms of the OPN gene were found between psoriasis and control groups. Limitations: The number of patients evaluated was relatively small. Conclusions: High plasma OPN levels are an unfavorable factor for development of cardiovascular disease in patients with psoriasis. (J Am Acad Dermatol 2008;60:225-30.)
URI: http://hdl.handle.net/11455/38269
ISSN: 0190-9622
文章連結: http://dx.doi.org/10.1016/j.jaad.2008.09.046
顯示於類別:生命科學系所

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。