請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/38275
標題: Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus
作者: Ho, K.T.
陳全木
Shiau, M.Y.
Chang, Y.H.
Chen, C.M.
Yang, S.C.
Huang, C.N.
關鍵字: innate immune-system
gene
cytokines
disease
asthma
mice
il4
macrophages
population
expression
期刊/報告no:: Metabolism-Clinical and Experimental, Volume 59, Issue 12, Page(s) 1717-1722.
摘要: Many factors have been implicated in the onset of type 2 diabetes mellitus (T2DM). Recently, immune response and inflammation were suggested to play certain roles in the development and complications of T2DM. The aim of this study is to investigate the putative correlation between the promoter polymorphisms of interleukin-4 (IL-4), one of the immune-regulatory type 2 helper T-cell cytokines, and T2DM. Genomic DNA from 425 Taiwanese T2DM patients and 148 nondiabetic control study subjects were extracted, and their IL-4 promoter polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism. Both of the distribution of IL-4 C-589T (P=.013) and C-34T (P=.05) genotypes were significantly different between T2DM patients and control subjects. Significant association between IL-4 C-589T alleles (P=.002) and T2DM, as well as C-34T alleles and T2DM (P=.024), was also identified. In addition, a statistically significant association between homologous IL-4 -589 C/C genotype and lower circulatory high-density lipoprotein cholesterol levels was observed. Our results suggested that IL-4 promoter polymorphisms are associated with T2DM. A significant association between IL-4 -589 C/C genotype and lower circulatory high-density lipoprotein cholesterol level was observed as well. The above results suggested that IL-4 may participate in lipid metabolism and diabetic susceptibility. (C) 2010 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/38275
ISSN: 0026-0495
文章連結: http://dx.doi.org/10.1016/j.metabol.2010.04.010
顯示於類別:生命科學系所

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