Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3829
標題: 角質層的水合作用對藥物經皮傳遞之研究
The Effect of Stratum Corneum Hydration on Transdermal Drug Delivery Process
作者: 施淳元
Shin, Chun-Yuan
關鍵字: hydration
水合作用
heat treatment
effective permeability
熱處理
有效滲透係數
出版社: 化學工程學系所
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摘要: 水在藥物經皮輸送系統中是常用的溶劑同時也是化學促滲劑(chemical enhancer),因此探討水對皮膚的影響,是一項值得探討的題目。在研究結果,我們希望能夠求得一系列不同親脂性藥物的有效滲透係數,各個藥物都將有一系列滲透係數在時間影響下的變化值,這項方法將幫助我們了解水合作用對藥物經皮傳遞之影響。本研究主要目的是希望使用簡易且精確的數值模型擬合(curve fitting)求得各類藥物之有效滲透係數,在能夠求得精準的滲透係數之前提下,我們希望能夠藉此量化在水合作用下各種不同親脂性(Ko/w)藥物之有效滲透係數變化程度,並試圖了解皮膚水合作用的機制。探討48小時內皮膚水合作用之實驗,期間以兩小時為間隔取得各個時間點之藥物累積滲透量,之後將此數據與數值模型進行擬合得到隨著時間產生變化之有效滲透係數。
Water not only serves as a solvent, but also is a chemical penetration enhancer in transdermal drug delivery system. Therefore, the hydration of skin is an important topic. In the study, we aim at obtaining a series of effective permeability coefficients of drugs, with a range of lipophilicity along with the corresponding drug release curves, which provide an important approach for the investigation of the effect of hydration on transdermal drug delivery. The main purpose of this study is to use a simple and accurate numerical model to fit the effective permeability coefficient for various drugs. as the precise quantification of effective permeability is obtained, attempts are made to elucidate the mechanism for the hydration of skin impacting the effective permeability of skin. And drugs of various lipophilicity(termed Ko/w) are investigated to study the correlation between lipophilicity of drug molecules and the hydration of the stratum corneum layer.
URI: http://hdl.handle.net/11455/3829
其他識別: U0005-1908201015401000
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1908201015401000
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