Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3830
標題: 水解反應對藥物經皮傳輸程序的影響之探討
Research in the Effect of Hydrolysis Reaction in the Transdermal Drug Delivery Process
作者: 褚鴻霖
Chu, Hong-Lin
關鍵字: Drug transdermal delivery
藥物經皮傳輸
Aspirin
Hydrolysis reaction
阿斯匹靈
水解反應
出版社: 化學工程學系所
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(2002). Handbook of essential pharmacokinetics, pharmacodynamics and drug metabolism for industrial scientists (New York, Kluwer Academic Publishers). 15.Loudon, G.M. (1991). Mechanistic interpretation of pH-rate profiles. Journal of Chemical Education 68, 973. 16.Mitragotri, S., and Kost, J. (2000). Low-Frequency Sonophoresis: A Noninvasive Method of Drug Delivery and Diagnostics. Biotechnology Progress 16, 488-492. 17.Mitragotri, S., and Kost, J. (2004). Low-frequency sonophoresis: A review. Advanced Drug Delivery Reviews 56, 589-601. 18.Naik, A., Kalia, Y.N., and Guy, R.H. (2000). Transdermal drug delivery: overcoming the skin''s barrier function. Pharmaceutical Science & Technology Today 3, 318-326. 19.Niu, H.-H., Lui, P.-W., Hu, J.S., Ting, C.-K., Yin, Y.-C., Lo, Y.-L., Liu, L., and Lee, T.-Y. (2001). Thermal Symmetry of Skin Temperature: Normative Data of Normal Subjects in Taiwan. Chinese Medical Journal (Taipei) 64, 459-468. 20.Potts, R., and Guy, R. (1992). Predicting Skin Permeability. Pharmaceutical Research 9, 663-669. 21.Prausnitz, M.R., Mitragotri, S., and Langer, R. (2004). Current status and future potential of transdermal drug delivery. Nat Rev Drug Discov 3, 115-124. 22.Schmook, F.P., Meingassner, J.G., and Billich, A. (2001). Comparison of human skin or epidermis models with human and animal skin in in-vitro percutaneous absorption. International Journal of Pharmaceutics 215, 51-56. 23.Singh, S., and Singh, J. (1993). Transdermal drug delivery by passive diffusion and iontophoresis: A review. Medicinal Research Reviews 13, 569-621. 24.Sintov, A.C., and Botner, S. (2006). Transdermal drug delivery using microemulsion and aqueous systems: Influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems. International Journal of Pharmaceutics 311, 55-62. 25.Some, I.T., Bogaerts, P., Hanus, R., Hanocq, M., and Dubois, J. (2000). 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摘要: 本文針對阿斯匹靈在經皮傳輸過程中同時發生水解反應的現象設計實驗加以探討,並且將反應效應加到了數值模型中,以便準確的定量有效滲透係數。在這個研究中,我們比較了各個參數對藥物經皮傳輸的影響,並且探討水解常數對所需用藥濃度的影響。同時改良的數值模型將給要端、皮膚與接受端的水解反應分開探討,使得數值模型的適用範圍更加寬廣,能夠各自觀察不同區域的水解反應對藥物傳輸能力的影響。此數值模型亦可作為定量經皮傳輸系統的基礎,特別是針對會在傳輸過程中發生反應的藥物。
The transdermal permeation of Aspirin associated with its hydrolysis reaction during the mass transfer process was studied in both experimental and modeling aspects. Using the Fickian diffusion model with two model variables, which represented effective skin permeability and the first-order hydrolysis rate constant in the skin, transdermal drug delivery process was quantified. This work characterizes the effect of numerical parameters in transport of the drug molecules across the skin, and deduces that the delivery efficiency has to be improved by using appropriate dosage form or permeation enhancement for the drug molecules that might encounter hydrolysis reaction during its percutaneous permeation. At the same time, our refined numerical model takes the hydrolysis reaction into consideration respectively at the zones of the donor solution, the skin tissue and the acceptor solution. The impacts of the reaction in these zones on the overall transdermal permeation are evaluated separately. The numerical model also provides a quantitative base for the application on transdermal drug delivery system, especially for these with chemical reaction in parallel with skin permeation.
URI: http://hdl.handle.net/11455/3830
其他識別: U0005-1908201015403000
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1908201015403000
Appears in Collections:化學工程學系所

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