Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38331
標題: Involvement of catecholamines in recall of the conditioned NK cell response
作者: Hsueh, C.M.
葛其梅
Kuo, J.S.
Chen, S.F.
Huang, H.J.
Cheng, F.C.
Chung, L.J.
Lin, R.J.
關鍵字: natural killer cell activity
catecholamine
norepinephrine
dopamine
conditioned response
natural-killer cells
beta-endorphin
receptor antagonists
memory
storage
time course
rats
epinephrine
amygdala
augmentation
enhancement
期刊/報告no:: Journal of Neuroimmunology, Volume 94, Issue 1-2, Page(s) 172-181.
摘要: The primary goal of the study was to identify the types of catecholamines and the associated receptors which might be involved in the recall of the conditioned NK cell response. Specific catecholamine receptor antagonists were selected to block the conditioned NK cell response at the recall step. The regional contents of dopamine (DA), norepinephrine (NE), and epinephrine were determined in the brain of the conditioned animals by using the high performance liquid chromatography with electrochemical detection (HPLC/ED). Results showed that pre-disruption of the central alpha 1-, alpha 2-, beta 1-, beta 2-, D1-, or D2-receptors at the conditioned recall stage, interrupted the conditioned enhancement in NK cell activity. The NE contents at the cerebellum, and DA contents at the striatum and hippocampus, were significantly higher in the brain of the conditioned animals when compared to that of the control animals. These information indicated the possible roles of the central noradrenergic and dopaminergic systems in regulating the recall of the conditioned NK cell response. (C) 1999 Elsevier Science B.V. All rights reserved.
URI: http://hdl.handle.net/11455/38331
ISSN: 0165-5728
文章連結: http://dx.doi.org/10.1016/s0165-5728(98)00250-1
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