Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3835
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dc.contributor湯正明zh_TW
dc.contributorCheng-Ming Tangen_US
dc.contributor.advisor戴憲弘zh_TW
dc.contributor.advisorShan-Hong Daien_US
dc.contributor.author朱柏旭zh_TW
dc.contributor.authorJu, Bo-Shiuen_US
dc.contributor.other中興大學zh_TW
dc.date2011zh_TW
dc.date.accessioned2014-06-06T05:32:53Z-
dc.date.available2014-06-06T05:32:53Z-
dc.identifierU0005-2008201016471900zh_TW
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dc.identifier.urihttp://hdl.handle.net/11455/3835-
dc.description.abstract本研究主要藉由改變水性聚胺酯(WBPU)的軟鏈節種類,由此可以改變WBPU的微相分離程度,以達到提升生物相容性的效果。以聚碳酸酯二元醇(PC diol)作為新的軟鏈節,合成出聚碳酸酯型水性聚胺酯(WBPCU),取代原本以聚醚二元醇(PTMO)作為軟鏈節所合成的聚醚型水性聚胺酯(WBPEU)。實驗結果發現,WBPCU其微相分離程度較WBPEU大,且氧化穩定性較高並由牛頸動脈內皮細胞(BEC)之貼附及增生和內皮性一氧化氮合成(eNOS)的基因表現實驗發現,當BEC培養在WBPCU時,其增生數量與eNOS的基因表現量皆較WBPEU還高。藉由混摻中尺寸奈米銀粒子和退火處理的方式改變WBPCU的微相分離程度,探討微相分離與機械性質的關係。實驗結果發現,混摻30 ppm與60 ppm的中尺寸奈米銀粒子均可降低WBPCU的楊氏係數(Young''s modulus)。對退火處理而言,經140退火處理後的材料其斷裂強度和拉伸率均有顯著上升。結果顯示,經過混摻和退火處理均能降低材料的微相分離程度,同時也提升WBPCU的機械性質。zh_TW
dc.description.abstractTwo types of waterborne polyurethane (WBPU) were synthesized in this study, including waterborne polyetherurethane (WBPEU) and waterborne polycarbonateurethane (WBPCU). The mechanical properties of WBPCU were further modified by either annealing treatment or addition of silver nanoparticles (AgNPs). WBPEU was found to have higher fracture strength and elongation than WBPCU. The microphase separation of WBPEU was less than that of WBPCU. The oxidation stability, on the other hand, was better for WBPCU. When AgNPs were added to WBPCU at 30 ppm or 60 ppm, the Young's modulus decreased (more compliant), but the fracture strength remained similar. When WBPCU was annealed at 140, both the fracture strength and elongation increased. Bovine carotid arterial endothelial cells (BEC) showed the higher cellular proliferation and eNOS gene expression when cultured on WBPCU.en_US
dc.description.tableofcontents目錄 摘要 I Abstract II 目錄 III 表目錄 VII 圖目錄 VIII 第一章 緒論 1 1-1 研究動機 1 1-2 研究目的 1 第二章 文獻回顧 2 2-1 組織工程 2 2-2 水性聚胺酯簡介 3 2-2 水性聚胺酯乳化方式 4 2-3 水性聚胺酯合成方式 5 2-4 聚胺酯生醫材料簡介 7 2-5 聚胺酯的生物相容性 8 2-6 奈米複合材料於生醫材料上之應用 9 2-7 內皮細胞(Endothelial cells) 9 第三章 研究方法 13 3-1實驗架構 13 3-2水性聚胺酯(Waterborn polyurethane, WBPU)的合成 15 3-2-1 聚碳酸酯型水性聚胺酯(Water borne poly(carbonate)urethane, WBPCU)的合成 15 3-2-2 聚醚型水性聚胺酯(Waterborne poly(ether)urethane, WBPEU)的合成 17 3-3 材料製備 19 3-3-1 油性聚胺酯 19 3-3-2 水性聚胺酯 19 3-3-3 水性聚胺酯奈米銀奈米複合材料 19 3-3-4 經退火處理(Annealing treatment)之水性聚胺酯 19 3-4 水性聚胺酯之物性測試 20 3-4-1 拉伸試驗 20 3-4-2 水性聚胺酯乳液粒徑分析 20 3-4-3 水性聚胺酯之熱性質分析 20 3-4-4 水性聚胺酯之原子力顯微鏡(Atomic force microscope, AFM)表面微結構分析 21 3-5 體外氧化穩定性測試 21 3-6 水性聚胺酯之生物相容性測試 21 3-6-1 細胞貼附測試 22 3-6-2 反轉錄-聚合連鎖反應(Reverse transcription-polymerase chain reaction, RT-PCR) 23 第四章 實驗結果 26 4-1聚碳酸酯型水性聚胺酯(Water borne polycarbonateurethane, WBPCU)的合成 26 4-2 水性聚胺酯之物性測試 26 4-2-1 拉伸試驗 26 4-2-2 水性聚胺酯乳液粒徑分析 27 4-2-3 熱性質分析 27 4-2-4 水性聚胺酯之原子力顯微鏡(Atomic force microscope, AFM)表面微結構分析 27 4-2-5 體外氧化穩定性測試 28 4-3 水性聚胺酯之生物相容性測試 28 4-3-1 細胞貼附及增生測試 28 4-3-2 反轉錄-聚合連鎖反應(Reverse transcription polymerase chain reaction, RT-PCR) 29 第五章 結果與討論 30 5-1 聚碳酸酯型水性聚胺酯(Water borne polycarbonateurethane, WBPCU)的合成與其粒徑分析 30 5-2 水性聚胺酯之物性測試 30 5-2-1 拉伸試驗 30 5-2-2 熱性質分析 31 5-2-3 水性聚胺酯之原子力顯微鏡(Atomic force microscope, AFM)表面微結構分析 31 5-2-4 體外氧化穩定性測試 32 5-3 水性聚胺酯之生物相容性測試 32 5-3-1 細胞貼附及增生測試 32 5-3-2 反轉錄-聚合連鎖反應(Reverse transcription polymerase chain reaction, RT-PCR) 32 第六章 結論 33 第七章 參考文獻 34 圖表 36zh_TW
dc.language.isoen_USzh_TW
dc.publisher化學工程學系所zh_TW
dc.relation.urihttp://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-2008201016471900en_US
dc.subjectwaterborne polycarbonateurethaneen_US
dc.subject聚碳酸酯型水性聚胺酯zh_TW
dc.subjectmicrophase separationen_US
dc.subjectsilver nanoparticlesen_US
dc.subjectbiocompatibilityen_US
dc.subjectdopingen_US
dc.subjectannealing treatmenten_US
dc.subject微相分離zh_TW
dc.subject生物相容性zh_TW
dc.subject奈米銀粒子zh_TW
dc.subject混摻zh_TW
dc.subject退火處理zh_TW
dc.title聚碳酸酯型水性聚胺酯的合成與生物相容性研究zh_TW
dc.titleSynthesis of Polycarbonate Type Waterborne Polyurethane and Biocompatibility Evaluationen_US
dc.typeThesis and Dissertationzh_TW
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