Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/38521
標題: Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response
作者: Pan, H.C.
蘇鴻麟
Sheu, M.L.
Su, H.L.
Chen, Y.J.
Chen, C.J.
Yang, D.Y.
Chiu, W.T.
Cheng, F.C.
許美鈴
期刊/報告no:: Magnesium Research, Volume 24, Issue 2, Page(s) 54-70.
摘要: Magnesium (Mg) supplements have been shown to significantly improve functional recovery in various neurological disorders. The essential benefits of Mg supplementation in peripheral nerve disorders have not been elucidated yet. The effect and mechanism of Mg supplementation on a sciatic nerve crush injury model was investigated. Sciatic nerve injury was induced in mice by crushing the left sciatic nerve. Mice were randomly divided into three groups with low-, basal-or high-Mg diets (corresponding to 10, 100 or 200% Mg of the basal diet). Neurobehavioral, electrophysiological and regeneration marker studies were conducted to explore nerve regeneration. First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations. In addition, Mg supplementation improved neurobehavioral, electrophysiological functions, enhanced regeneration marker, and reduced deposits of inflammatory cells as well as expression of inflammatory cytokines. Furthermore, reduced Schwann cell apoptosis was in line with the significant expression of bcl-2, bcl-X(L) and down-regulated expression of active caspase-3 and cytochrome C. In summary, improved neurological function recovery and enhanced nerve regeneration were found in mice with a sciatic nerve injury that were fed a high- Mg diet, and Schwann cells may have been rescued from apoptosis by the suppression of inflammatory responses.
URI: http://hdl.handle.net/11455/38521
ISSN: 0953-1424
文章連結: http://dx.doi.org/10.1684/mrh.2011.0280
Appears in Collections:生命科學系所

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.