Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3896
標題: 利用數值模型定量膠囊釋放之行為
The Quantification of Capsule-Drug Release with a Mathematical Model
作者: 謝明哲
Shieh, Ming-Che
關鍵字: Capsule
膠囊
Mathematical model
數值模型
出版社: 化學工程學系所
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E., Manufacture and properties of two-piece hard capsules, Pharmaceutical capsules, (2004). [22] Koizumi, T., Ritthidej, G. C., Phaechamud, T., Mechanistic modeling of drug release from chitosan coated tablets, Journal of controlled release, 70 3 (2001) 277-284. [23] Ludwig, A., Van Ooteghem, M., Disintegration of Hard Gelatin Capsules, part 2: Disintegration mechanism of hard gelatin capsules investigated with a stereoscopic microscope, Pharm. Ind, 42 (1980) 405-406. [24] Pina, M., Sousa, A., Brojo, A., Enteric coating of hard gelatin capsules. Part 1. Application of hydroalcoholic solutions of formaldehyde in preparation of gastro-resistant capsules, International journal of pharmaceutics, 133 1-2 (1996) 139-148. [25] Pina, M., Sousa, A., Brojo, A., Enteric coating of hard gelatin capsules. Part 2--Lioavailability of formaldehyde treated capsules, International journal of pharmaceutics, 148 1 (1997) 73-84. [26] Podczeck, F., Pharmaceutical capsules, Pharmaceutical Pr, (2004). 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摘要: 在疾病的治療過程中,藥物的使用是不可或缺的一環,在藥物的使用上,要達到控制藥物釋放又是一門重要的學問。藥物的載體以錠劑及膠囊兩種劑型為大宗,其中又以膠囊劑型為最常使用之載體,這是由於膠囊的靈活性,填充藥物的狀態可多變,不管是固體藥物或是液體藥物,甚至是半固體藥物,均可充填至膠囊內,使藥物不致洩露出來。因此了解膠囊藥物的釋放極為重要,本研究主要目的即是推導出膠囊釋放之數值模型,再以此數值模型與膠囊的釋放曲線進行擬合,定量出有效擴散係數和遲滯時間。實驗中的膠囊有以下幾種不同的控制變因,包含腰帶的有無、封膜的有無、充填物的飽滿度、以及不同釋放環境,針對不同類型的膠囊所得到的釋放曲線,與數值模型擬合,得到該情況下之遲滯時間,以及有效擴散係數。
Study of drug release for treatment of disease is very important, the utility drug carriers such as tablet and capsule, the latter is more practical than the former. Owing to adaptability of the capsules, it is changeful in the filling types of drugs. No matter what the filling types of drugs are solid, liquid, or semi-solid, a drug filled into a capsule is completely. Consequently, it is more important for everyone to study the capsule-drug release. In this study, we derived a mathematical model to describe the drug release in capsule, and to quantify the effective diffusion coefficient and lag time with the experimental data. During experiment, the capsules had different types, including with or without belt and film, full degree of the drug, and the different kinds of bulk solution. Then, the mathematical model was fitting with data, therefore, obtained the effective diffusion coefficient and lag time in each case.
URI: http://hdl.handle.net/11455/3896
其他識別: U0005-1508201116254200
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1508201116254200
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