Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3900
標題: 以聚乳酸二元醇製備兼具生物可分解及生物相容性之聚胺酯/尿素
Synthesis of Biodegradable and Biocompatible Polyurethane/urea Containing Polylactiode Diol
作者: 林惠美
Lin, Hui-Mei
關鍵字: Polylactide diol
聚乳酸二元醇
Biodegradable
Biocompatible
Polyurethane
生物可分解
生物相容性
聚胺酯
出版社: 化學工程學系所
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摘要: 本研究主要探討如何利用化學合成方式,結合聚乳酸二元醇(PLA-diol-2000)與聚胺酯(Polyurethane, PU),設計出一種新型的綠色材料。首先利用1,4-丁二醇(1,4-Butandiol, 1,4-BDO)作為起始劑,與L型乳酸交酯(L-Lactide)進行開環聚合(Ring-Opening Polymerization, ROP),可合成出Mn約為1,800 g/mol之L型聚乳酸二元醇(PLA-diol-2000),並以此做為PU軟鏈段中重要的組成。而配方當中,其他的原料則選用聚酯二元醇(Diol of Polyethylene-Butylene-Adipate, RS-956)、聚四亞甲基醚二醇(Polytetramethylene Ether Glycol, PTMEG-2000)、異弗爾酮二異氰酸鹽(Isophorone Diisocyanate, IPDI)、1,4-丁二醇及1,4-丁二胺(1,4-Butanediamine, 1,4-BDA)。 本研究中找出適合含PLA-diol-2000之PU的合成方法,所合成之PU具有極佳的生物相容性,亦為一可分解材料,且針對其性質進行分析,包括分子量、熱性質及機械性質。另外,也利用PLA-diol-2000、PTMEG與RS-956(以1:1:3之比例混合)作為軟鏈段,1,4-BDO及1,4-BDA(以1:1之比例混合)作為鏈延長劑,進而設計出另一PU配方。未來,此類綠色材料可望在特殊醫學應用上發揮很大的潛力。
In this study, we have combined the chemical processing of PLA-diol-2000 into polyurethanes (PUs) in our design of new green materials. PLA-diol-2000 of 1,800 molecular weight was synthesized from 1,4-butanediol and L-lactide through ring-opening polymerization, and was used as the key component of soft segment of PUs. Other common raw materials used in our formulation developments were diol of polyethylene-butylene-adipate (RS-956), polytetramethylene ether glycol (PTMEG), isophorone diisocyanate (IPDI), 1,4-butanediol (1,4-BDO) and 1,4-butanediamine (1,4-BDA). The suitable process for synthesis of PUs with PLA-diol-2000 was studied, and the characteristics of synthesized PUs containing PLA-diol-2000 were analyzed, including molecular weights, thermal properties and mechanical properties. From this study, we have come up with PUs possessing balanced properties that exhibit excellent biocompatibility and biodegradability. This is achieved by the combination of PLA-diol-2000/PTMEG/RS-956 (in ratio of 1/1/3, respectively) as the soft segment constituents with BDO and BDA (in ratio of 1/1, respectively) as the hard segment ingredients in our formulation. The green materials show great potential for use in the special medical applications.
URI: http://hdl.handle.net/11455/3900
其他識別: U0005-1608201117444000
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1608201117444000
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