Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3938
標題: The Role of Drug Molecular Structure on Transdermal Delivery Processes Exemplified by Salicylic Acid and Acetylsalicylic Acid
藥物分子結構在經皮吸收過程中所扮演的角色:以水楊酸和阿斯匹靈為例
作者: 王怡芳
Wang, Yi-Fang
關鍵字: effective permeability
滲透係數
mathematical model
structure-activity
數值模型
分子結構活性
出版社: 生醫工程研究所
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摘要: 藥物經皮輸送系統(TDDS),是一種藥物分子藉由局部投予的方式,控制藥物持續穿透皮膚,甚至釋放到全身血液循環,達到治療效果。TDDS最大的阻力是皮膚角質層,因此針對角質層其結構及特性,可利用物理性、化學性促進方法來提高經皮吸收效率。本研究利用垂直式Franz Diffusion Cell進行in vitro滲透實驗,使用尿素、水楊酸與阿斯匹靈藥物分子滲透豬皮組織,以高效能液相層析儀為定量工具,之將各藥物分子之累積滲透量對時間作圖,並配合數值模型量化皮膚之滲透係數。 關於尿素分子定量法,電導度法定量出的滲透係數與高效能液相層析儀定量法在同一數量級,驗證了電導度法之準確性。水楊酸與阿斯匹靈分子結構相似,但實驗結果顯示兩者滲透係數有所差異,推論原因可能為藥物分子結構活性(親脂性、分子量、分子莫爾體積大小)與滲透係數有所關聯性,並經由文獻證實其推論,未來期望可利用數值模型定量出皮膚滲透係數,控制藥物釋放行為。
Transdermal Drug Delivery System (TDDS) finds a variety of applications in drug delivery nowadays and is viewed a potential method in controlled release of drug. Currently, it is widely accepted that stratum corneum (SC) composes the major diffusional resistance in transdermal diffusion process. Therefore it demands elucidation on structure and characteristics of SC in order to improve the efficacy of drug delivery with physical and chemical protocols. The drug molecules including urea, salicylic acid and aspirin are allowed to permeate through skin sample mounted on Franz diffusion cells (FDC). In the in vitro experiment the real time concentration of the sample solution are recorded and quantified by High Performance Liquid Chromatography (HPLC). In parallel, a simple diffusion model is developed, attempting to describe this mass transport process with diffusion theories mathematically. Output of the comparison between model data and experimental results generates the permeability of the skin. Permeabilities determined with the mathematical model and HPLC in this work are checked against previous work, in which Electrical Conductivity was employed to quantify the concentration of sample solution. Comparison between them confirms the accuracy of both experimental methods (HPLC and EC). Physicochemical factors including lipophilicity, molecular weight, molar volume are elucidated for permeating probes, aiming at interpreting the potential mechanisms underlying the transdermal drug delivering process.
URI: http://hdl.handle.net/11455/3938
其他識別: U0005-2307200914474400
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-2307200914474400
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