Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3945
標題: 膠囊設計對藥物釋放行為影響之定量研究
The Quantitative Research of Drug Release for Hard Capsules
作者: Yao, Li-Yu
姚立羽
關鍵字: capsule
膠囊
drug release
藥物釋放
出版社: 生醫工程研究所
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摘要: The Oral Drug Delivery System (ODDS) is designed to control drug release by maintaining the drug concentration constant in blood and reaching the optimal efficacy. The most effective implementation of control release is to coat the drug with designed material which is sensitive to certain conditions e.g., pH values, release time, etc. Among the variety of coating methods, capsulation is the mostly employed. This work investigate the common manipulated parameters of capsulation, including drug filling amount, capsule size, conditions of bulk solution, sealing, and coating. The electrical conductivity method was used to determine the drug concentration for its satisfactory accuracy, convenience and relatively low cost compared to High Performance Liquid Chromatography (HPLC). With the mathematical model, the quantification of the drug release from capsules is thus feasible.
口服藥物傳輸系統(ODDS),主要的目標都是為了達到控制釋放,使藥物在血液中濃度固定,使其發揮最大療效。藥物控制釋放常見的方式,一般多以將藥物用特殊的化學材質包覆,使藥物在某一種狀態下適時適量釋出,例如:PH值改變、延長釋放時間等。膠囊則是最早、最常見也最方便的一種藥物包覆方式。本研究針對常見的膠囊變因,例如:填充量、大小、釋放環境探討其釋放行為,更進一步探討目前硬膠囊足以取代軟膠囊的技術-腰帶(sealing),以及藥物走向控制釋放的關鍵-膜衣(coating)。將實驗結果配合數值模型量化出藥物的擴散係數。並由實驗結果知膠囊此類特殊構形之釋放行為。使用電導度法做定量,避免了一般光學儀器容易因為色素造成的影響,且其精確度與高效能液相層析儀定量法在同一數量級,又攜帶方便、實用。
URI: http://hdl.handle.net/11455/3945
其他識別: U0005-1608201114215600
文章連結: http://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1608201114215600
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