請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/40216
標題: Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer
作者: Huang, T.T.
林季千
Yen, M.C.
Lin, C.C.
Weng, T.Y.
Chen, Y.L.
Lin, C.M.
Lai, M.D.
關鍵字: t-cell responses
unresectable hepatocellular-carcinoma
plasmacytoid
dendritic cells
draining lymph-nodes
hepatoma model
dna vaccine
phase-ii
2,3-dioxygenase
therapy
tumors
期刊/報告no:: Cancer Science, Volume 102, Issue 12, Page(s) 2214-2220.
摘要: Liver cancer is one of the most malignant cancers in the world and has a high rate of metastasis. Therefore, development of a novel therapy for liver cancer is a critical issue. Indoleamine 2,3-dioxygenase (IDO) is known as a negative immune regulator in dendritic cells. Our previous study demonstrated that skin delivery of IDO short hairpin RNA (shRNA) induced antitumor immunity in subcutaneous bladder and colon tumor models. Because the immunological environment is quite different between skin and liver, it is essential to evaluate whether skin delivery of IDO shRNA is an effective treatment in metastatic and orthotopic animal tumor models. In the present study, IDO shRNA inhibited tumor growth in subcutaneous, metastatic and orthotopic liver tumor models. The cytotoxicity of splenocytes was significantly elevated in mice treated with IDO shRNA in the orthotopic and metastatic tumor models. Interleukin (IL)-12 and interferon (IFN)-gamma mRNA expression were upregulated while IL-10 was downregulated in the inguinal lymph nodes, which were collected from IDO shRNA-treated mice. Similar results were observed in the spleens of mice inoculated with IDO shRNA by gene gun. The results indicate that skin administration of IDO shRNA is an effective therapy in orthotopic and metastatic liver cancer animal models. Indoleamine 2,3-dioxygenase shRNA might be a potential new treatment for liver cancer in the future. (Cancer Sci 2011; 102: 22142220)
URI: http://hdl.handle.net/11455/40216
ISSN: 1347-9032
文章連結: http://dx.doi.org/10.1111/j.1349-7006.2011.02094.x
顯示於類別:生物醫學研究所

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