請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/40220
標題: The associations of circulating CD4(+)CD25(high) regulatory T cells and TGF-beta with disease activity and clinical course in patients with adult-onset Still's disease
作者: Chen, D.Y.
林季千
Chen, Y.M.
Chen, H.H.
Hsieh, C.W.
Lin, C.C.
Lan, J.L.
關鍵字: CD4(+)CD25(high) regulatory T cells
transforming growth factor-beta
adult-onset Still's disease
systemic lupus erythematosus
disease
activity
systemic-lupus-erythematosus
growth-factor-beta
immunological
self-tolerance
human peripheral-blood
tnf-alpha therapy
rheumatoid-arthritis
functional-characterization
foxp3 expression
activity index
population
期刊/報告no:: Connective Tissue Research, Volume 51, Issue 5, Page(s) 370-377.
摘要: Objective. To determine circulating levels of CD4(+)CD25(high) regulatory T (Treg) cells and transforming growth factor-beta (TGF-beta) in patients with adult-onset Still's disease (AOSD) and to examine the associations with disease activity and clinical course of this disease. Methods. The frequencies of circulating CD4(+)CD25(high) Treg cells in 52 active AOSD patients, 42 active systemic lupus erythematosus (SLE) patients, and 22 healthy controls (HCs) were determined using flow cytometry analysis. Levels of serum TGF-beta and soluble interleukin-2 receptor (sIL-2R) were measured by enzyme-linked immunosorbent assay. Results. Significantly lower levels of circulating CD4(+)CD25(high) Treg cells and serum TGF-beta were found in AOSD patients and SLE patients than those found in HCs. Levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta were inversely correlated with disease activity scores for AOSD patients and SLE patients. Circulating CD4(+)CD25(high) Treg cell frequencies were positively correlated with serum TGF-beta levels for patients with both diseases. Levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta significantly increased, paralleling clinical remission and the decrease in levels of C-reactive protein and soluble interleukin-2 receptor after effective therapy in AOSD patients. AOSD patients with monocyclic course had significantly higher levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta compared to those with polycyclic and chronic articular course. Conclusion. Diminished levels of circulating CD4(+)CD25(high) Treg cells and TGF-beta, and inverse correlation with disease activity in patients with AOSD and SLE might be involved in the pathogenesis of both diseases. Increased levels of circulating CD4(+)CD25(high) Treg cells or TGF-beta might be associated with a favorable clinical course in AOSD patients.
URI: http://hdl.handle.net/11455/40220
ISSN: 0300-8207
文章連結: http://dx.doi.org/10.3109/03008200903461462
顯示於類別:生物醫學研究所

文件中的檔案:
沒有與此文件相關的檔案。


在 DSpace 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。