請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/40236
標題: Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease
作者: Chen, D.Y.
林季千
Chen, Y.M.
Lan, J.L.
Lin, C.C.
Chen, H.H.
Hsieh, C.W.
關鍵字: T helper type 17 cells
T helper type 17-related cytokines
Pathogenesis
Adult-onset Still's disease
Systemic lupus erythematosus
systemic-lupus-erythematosus
rheumatoid-arthritis
t-cells
proinflammatory cytokines
pathological tissues
joint inflammation
bone erosion
interleukin-17
il-17
distinct
期刊/報告no:: Rheumatology, Volume 49, Issue 12, Page(s) 2305-2312.
摘要: Methods. The frequencies of circulating Th17 cells in 24 patients with active untreated AOSD, 16 patients with active SLE and 12 healthy volunteers were determined using intracellular cytokine staining and flow cytometry. Serum levels of Th17-related cytokines, including IL-1 beta, IL-6, IL-17, IL-18, IL-21 and IL-23 were measured by ELISA. Results. Significantly higher median frequencies of circulating Th17 cells were found in active untreated AOSD patients (1.01%) and active SLE patients (1.26%) than in healthy volunteers (0.12%, both P < 0.001). The frequencies of circulating Th17 cells were positively correlated with activity score (r = 0.527, P < 0.01) and serum ferritin levels (r = 0.724, P < 0.001) in AOSD patients, and correlated with SLEDAI (r = 0.663, P < 0.01) in SLE patients. Additionally, the frequencies of circulating Th17 cells were positively and significantly correlated with serum levels of IL-1 beta, IL-6, IL-17, IL-18, IL-21 and IL-23 in both AOSD and SLE patients. The frequencies of circulating Th17 cells and serum IL-17 levels significantly decreased after effective therapy in AOSD patients (both P < 0.001). Conclusion. Elevated frequencies of circulating Th17 cells and a positive correlation with disease activity in our AOSD patients suggest that Th17 cells contribute to the pathogenesis of this disease. Dysregulation of Th17 cells may be a common pathogenic mechanism that underlies the development of both AOSD and SLE.
URI: http://hdl.handle.net/11455/40236
ISSN: 1462-0324
文章連結: http://dx.doi.org/10.1093/rheumatology/keq284
顯示於類別:生物醫學研究所

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