請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/40417
標題: MicroRNA signature predicts survival and relapse in lung cancer
作者: Yu, S.L.
陳健尉
Chen, H.Y.
Chang, G.C.
Chen, C.Y.
Chen, H.W.
Singh, S.
Cheng, C.L.
Yu, C.J.
Lee, Y.C.
Chen, H.S.
Su, T.J.
Chiang, C.C.
Li, H.N.
Hong, Q.S.
Su, H.Y.
Chen, C.C.
Chen, W.J.
Liu, C.C.
Chan, W.K.
Li, K.C.
Chen, J.J.W.
Yang, P.C.
劉俊吉
關鍵字: gene-expression
adjuvant chemotherapy
cell lines
let-7
prognosis
adenocarcinoma
tumors
oncogenes
targets
model
期刊/報告no:: Cancer Cell, Volume 13, Issue 1, Page(s) 48-57.
摘要: We investigated whether microRNA expression profiles can predict clinical outcome of NSCLC patients. Using real-time RT-PCR, we obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets. Using Cox regression and risk-score analysis, we identified a five-microRNA signature for the prediction of treatment outcome of NSCLC in the training set. This microRNA signature was validated by the testing set and an independent cohort. Patients with high-risk scores in their microRNA signatures had poor overall and disease-free survivals compared to the low-risk-score patients. This microRNA signature is an independent predictor of the cancer relapse and survival of NSCLC patients.
URI: http://hdl.handle.net/11455/40417
ISSN: 1535-6108
文章連結: http://dx.doi.org/10.1016/j.ccr.2007.12.008
顯示於類別:生物醫學研究所

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