請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/40423
標題: Anticancer effects of tanshinone I in human non-small cell lung cancer
作者: Lee, C.Y.
陳健尉
Sher, H.F.
Chen, H.W.
Liu, C.C.
Chen, C.H.
Lin, C.S.
Yang, P.C.
Tsay, H.S.
Chen, J.J.W.
劉俊吉
關鍵字: nonsteroidal antiinflammatory drugs
salvia-miltiorrhiza bunge
nf-kappa-b
therapy enhances expression
growth-factor b
endothelial-cells
interleukin-8 expression
macrophage infiltration
tumor angiogenesis
patient survival
期刊/報告no:: Molecular Cancer Therapeutics, Volume 7, Issue 11, Page(s) 3527-3538.
摘要: Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine. We investigated the anticancer effects of tanshinones on the highly invasive human lung adenocarcinoma cell line, CL 1-5. Tanshinone I significantly inhibited migration, invasion, and gelatinase activity in macrophage-conditioned medium-stimulated CL 1-5 cells in vitro and also reduced the tumorigenesis and metastasis in CL 1-5-bearing severe combined immunodeficient mice. Unlike tanshinone IIA, which induces cell apoptosis, tanshinone I did not have direct cytotoxicity. Real-time quantitative PCR, luciferase reporter assay, and electrophoretic mobility shift assay revealed that tanshinone I reduces the transcriptional activity of interleukin-8, the angiogenic factor involved in cancer metastasis, by attenuating the DNA-binding activity of activator protein-1 and nuclear factor-kappa B in conditioned medium-stimulated CL 1-5 cells. Microarray and pathway analysis of tumor-related genes identified the differentially expressed genes responding to tanshinone 1, which may be associated with the Ras-mitogen-activated protein kinase and Rac1 signaling pathways. These results suggest that tanshinone I exhibits anticancer effects both in vitro and in vivo and that these effects are mediated at least partly through the interleukin-8, Ras-mitogen-activated protein kinase, and Rac1 signaling pathways. Although tanshinone I has a remarkable anticancer action, its potential anticoagulant effect should be noted and evaluated. [Mol Cancer Ther 2008;7(11):3527 - 38]
URI: http://hdl.handle.net/11455/40423
ISSN: 1535-7163
文章連結: http://dx.doi.org/10.1158/1535-7163.mct-07-2288
顯示於類別:生物醫學研究所

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