Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40444
標題: HGF increases cisplatin resistance via down-regulation of AlF in lung cancer cells
作者: Chen, J.T.
邱繡河
Huang, C.Y.
Chiang, Y.Y.
Chen, W.H.
Chiou, S.H.
Chen, C.Y.
Chow, K.C.
周寬基
關鍵字: apoptosis inducing factor
cisplatin resistance
hepatocyte growth
factor
focal adhesion kinase
non-small cell lung cancer
hepatocyte growth-factor
apoptosis-inducing factor
focal adhesion
kinase
factor protects
death
overexpression
invasion
pneumocytes
neurons
fak
期刊/報告no:: American Journal of Respiratory Cell and Molecular Biology, Volume 38, Issue 5, Page(s) 559-565.
摘要: Our previous study had shown that advanced stages of lung adenocarcinomas (ADC) was frequently associated with overexpression of hepatocyte growth factor (HGF), which has multipotent and antiapoptotic activities. In this study, we examined the effect of HGF on gene expression of apoptosis-inducing factor (AIF) and cisplatin sensitivity in lung ADC cells. Expression of AIF was determined by immunocytochemistry and confocal immunofluorescence microscopy. Our data show that addition of HGF suppressed AIF expression and increased cisplatin resistance. The effect could be through HGF receptor and its downstream effector, focal adhesion kinase (FAK). Interestingly, knockout of FAK gene increased AIF expression and drug sensitivity. Re-introduction of FAK gene, on the other hand, restored drug resistance. These results suggested that HGF might induce cisplatin resistance via c-Met to activate FAK and down-regulate AIF expression.
URI: http://hdl.handle.net/11455/40444
ISSN: 1044-1549
文章連結: http://dx.doi.org/10.1165/rcmb.2007-0001OC
Appears in Collections:生物醫學研究所

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