Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40445
標題: Infection of human papillomavirus and overexpression of dihydrodiol dehydrogenase in uterine cervical cancer
作者: Ueda, M.
邱繡河
Hung, Y.C.
Chen, J.T.
Chiou, S.H.
Huang, H.H.
Lin, T.Y.
Terai, Y.
Chow, K.C.
周寬基
關鍵字: HPV
DDH
uterine cervical cancer
survival
drug resistance
carcinoma cell-lines
intraepithelial neoplasia
human liver
in-vitro
interleukin-6
expression
dna
resistance
proliferation
purification
期刊/報告no:: Gynecologic Oncology, Volume 102, Issue 2, Page(s) 173-181.
摘要: Objective. To determine the association of human papillomavirus (HPV) infection with the expression of dihydrodiol dehydrogenase (DDH) in uterine cervical cancer (UCC). Methods. In situ hybridization (ISH) and immunohistochemistry were applied to examine pathological specimens of 145 patients with UCC. Results. By ISH, HPV16/18 DNA was detected in 108 (74.5%) UCC cases. DDH expression determined by immunohistochemistry was detected in 81 (75%) lesions among 108 HPV-positive cases. In contrast, of 37 HPV-negative cases, DDH was only detected in 16 (43.2%) of the lesions. A significant correlation was found between DDH expression and the presence of HPV (P < 0.001), FIGO stage (P = 0.004), lymph node involvement (P < 0.001), as well as patients' survival (P = 0.002). In vitro, DDH expression was also found closely associated with HPV infection, and DDH content was proportional to cell sensitivity for cisplatin and doxorubicin. Conclusions. HPV infection provokes local inflammation, which can then induce DDH expression and drug resistance in UCC. The detailed biological relationship among HPV infection, expression of DDH and drug resistance, however, remains to be clarified. (c) 2005 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/40445
ISSN: 0090-8258
文章連結: http://dx.doi.org/10.1016/j.ygyno.2005.12.009
Appears in Collections:生物醫學研究所

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