Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/40488
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dc.contributor.authorLai, T.C.en_US
dc.contributor.author周寬基zh_TW
dc.contributor.authorChow, K.C.en_US
dc.contributor.authorLin, T.Y.en_US
dc.contributor.authorChiang, I.P.en_US
dc.contributor.authorFang, H.Y.en_US
dc.contributor.authorChen, C.Y.en_US
dc.contributor.authorHo, S.P.en_US
dc.contributor.author何素鵬zh_TW
dc.date2010zh_TW
dc.date.accessioned2014-06-06T08:03:50Z-
dc.date.available2014-06-06T08:03:50Z-
dc.identifier.issn1021-335Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/40488-
dc.description.abstractDNA repair is one of the major causes of spontaneous drug and radiation resistance in patients with lung adenocarcinomas (LADC). 53BP1 is a mediator that relays signals from DNA damage sensors and activates various effectors for the DNA repair and cell survival. In this study we investigated the clinical and biological significance of 53BP1. Expression of 53BP1 was detected by immunoblotting and immunohistochemistry. Our data showed that 53BP1 was detected in 166 (75.8%) of 219 LADC patients. Expression of 53BP1 correlated with tumor stage, cigarette smoking, lymphovascular invasion and poor clinical outcome. In vitro, increased 53BP1 expression elevated drug resistance, and silencing of 53BP1 expression reduced cisplatin resistance. Our results suggest that 53BP1 expression plays an important role in cisplatin resistance and predicts the prognosis for LADC.en_US
dc.language.isoen_USzh_TW
dc.relationOncology Reportsen_US
dc.relation.ispartofseriesOncology Reports, Volume 24, Issue 2, Page(s) 321-328.en_US
dc.relation.urihttp://dx.doi.org/10.3892/or_00000862en_US
dc.subject53BP1en_US
dc.subjectDNA repairen_US
dc.subjectcisplatin resistanceen_US
dc.subjectlung adenocarcinomaen_US
dc.subjectcigaretteen_US
dc.subjectsmokingen_US
dc.subjectinterstrand cross-linken_US
dc.subjectdna-damageen_US
dc.subjectcancer cellsen_US
dc.subjectrepairen_US
dc.subjectp53en_US
dc.subjectcheckpointen_US
dc.subjectacetaldehydeen_US
dc.subjectinstabilityen_US
dc.subjectprogressionen_US
dc.subjectinductionen_US
dc.titleExpression of 53BP1 as a cisplatin-resistant marker in patients with lung adenocarcinomasen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.3892/or_00000862zh_TW
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