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dc.contributor.authorYeh, Chung-Hsinen_US
dc.contributor.authorHsieh, Ming-Tsuenen_US
dc.contributor.authorHsueh, Chi-Meien_US
dc.contributor.authorWu, Chi-Reien_US
dc.contributor.authorHuang, Yi-Chunen_US
dc.contributor.authorLiao, Jiunn-Wangen_US
dc.contributor.authorChow, Kuan-Chihen_US
dc.description.abstractAlzheimer's disease (AD) is an irreversible neurodegenerative disorder characterized by amyloid accumulation, neuronal death, and cognitive impairments. Yi-Chi-Tsung-Ming-Tang (YCTMT) is a traditional Chinese medicine and has never been used to enhance cognitive function and treat neurodegenerative disorders such as senile dementia. Whether YCTMT has a beneficial role in improving learning and memory in AD patients remains unclear. The present study showed that oral administration of YCTMT ameliorated amyloid-β- (Aβ1−40) injection-induced learning and memory impairments in rats, examined using passive avoidance and Morris water-maze tests. Immunostaining and Western Blot results showed that continuous Aβ1−40 infusion caused amyloid accumulation and decreased acetylcholine level in hippocampus. Oral administration of medium and high dose of YCTMT 7 days after the Aβ1−40 infusion decreased amyloid accumulation area and reversed acetylcholine decline in the Aβ1−40-injected hippocampus, suggesting that YCTMT might inhibit Aβ plague accumulation and rescue reduced acetylcholine expression. This study has provided evidence on the beneficial role of YCTMT in ameliorating amyloid-induced AD-like symptom, indicating that YCTMT may offer an alternative strategy for treating AD.en_US
dc.relationEvidence-Based Complementary and Alternative Medicine, Volume 2012en_US
dc.titleTherapeutic Effect of Yi-Chi-Tsung-Ming-Tang on Amyloid β1−40-Induced Alzheimer's Disease-Like Phenotype via an Increase of Acetylcholine and Decrease of Amyloid βen_US
dc.typeJournal Articlezh_TW
dc.contributor.catalogerWei Chun Wangen_US
Appears in Collections:生物醫學研究所


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