Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/41080
標題: Improved cell adhesion by plasma-induced grafting of L-lactide onto polyurethane surface
作者: Hsu, S.H.
徐善慧
Chen, W.C.
關鍵字: L-lactide
polyurethane
plasma-induced surface grafting
biodegradability
cell adhesion
platelet activation
human-endothelial-cells
platelet-adhesion
glow-discharge
glycol)
methacrylate
polyethylene surface
polymer surfaces
attachment
copolymerization
compatibility
growth
期刊/報告no:: Biomaterials, Volume 21, Issue 4, Page(s) 359-367.
摘要: Lactide-grafted polyurethanes were prepared by exposing the polyurethane films to argon plasma discharge, followed by grafting L-lactide onto the plasma-treated surface. The modified surfaces were characterized by measuring the static contact angle and by electron spectroscopy for chemical analysis (ESCA). The water contact angle of polyurethanes was decreased by L-lactide grafting, indicating hydrophilicity of the modified surface. Grafting also increased the O/C atomic ratio and C-C=O/C-total percentage on the surfaces as detected by ESCA. The grafted surfaces showed enhanced attachment and growth in both 3T3 fibroblast and human umbilical vein endothelial cell culture tests. Platelet adhesion to the modified surfaces was also reduced in vitro. L-Lactide monomers grafted onto polyurethane substrates could therefore be useful in facilitating endothelial cell seeding process in small vascular graft applications. (C) 2000 Elsevier Science Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/41080
ISSN: 0142-9612
文章連結: http://dx.doi.org/10.1016/s0142-9612(99)00191-x
Appears in Collections:化學工程學系所

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