Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/41252
標題: Preparation and characterization of amphiphilic poly(ethylene glycol) graft copolymers
作者: Chiu, H.C.
邱信程
Hu, C.H.
Chern, C.S.
關鍵字: amphiphilic copolymers
polymeric micelles
poly(ethylene glycol)
fluorescence emission
quenching
block copolymers
conformational state
aqueous-solution
excluded-volume
drug carriers
side-chains
oxide)
association
fluorescence
micelles
期刊/報告no:: Polymer Journal, Volume 31, Issue 6, Page(s) 535-541.
摘要: Amphiphilic graft copolymers of alkyl methacrylates, methoxy poly(ethylene glycol) (PEG) acrylate, and acrylic acid were synthesized by free radical polymerization. PEG graft copolymers with respect to structure, composition, and average molecular weight were characterized by FT-IR,H-1 NMR, and GPC. The critical micelle concentration and molar mass of the polymeric micelles were determined by fluorescence spectroscopy using pyrene as the fluorescence probe and static laser light scattering, respectively. The formation of polymeric micelles was influenced by the balance of hydrophobicity and hydrophilicity and other factors such as molecular weight of the copolymer products. The molar mass of polymeric micelles increased with mole content of hydrophobic comonomers. Loading capacity and weight average partition coefficient for the pyrene molecules into polymeric micelles were estimated via fluorescence quenching by Cu2+. Fluorescence quenching studies of pyrene indicated that a loose structure of micelles was formed from the graft copolymer containing high content of hydrophilic monomethoxy poly(ethylene glycol) (mPEG) and acrylic acid.
URI: http://hdl.handle.net/11455/41252
ISSN: 0032-3896
文章連結: http://dx.doi.org/10.1295/polymj.31.535
Appears in Collections:化學工程學系所

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