Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/41355
DC FieldValueLanguage
dc.contributor.authorHsu, S.H.en_US
dc.contributor.author徐善慧zh_TW
dc.contributor.authorChuang, S.C.en_US
dc.contributor.authorChen, C.H.en_US
dc.contributor.authorChen, D.C.en_US
dc.date2006zh_TW
dc.date.accessioned2014-06-06T08:05:25Z-
dc.date.available2014-06-06T08:05:25Z-
dc.identifier.issn0959-2989zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/41355-
dc.description.abstractPreviously we have fabricated the small diameter polyurethane (Pellethane 2363-80A, abbreviated PU) vascular grafts that were modified by epoxy-crosslinked gelatin (abbreviated gelatin) and an RGD-containing protein (abbreviated CBD-RGD) to facilitate the endothelial cell (EC) seeding on the surface. In this study, the biocompatibility of such surface after freeze-drying and gamma irradiation was evaluated. The contact angle of the irradiated PU dropped a little and the ESCA spectra revealed oxygen bonding. The increases in the amount of extractables as well as in the molecular weight distribution were observed. The mechanical properties decreased only slightly. The irradiated PU surface showed enhanced EC affinity that persisted after several months of storage. Gelatin, CBD-RGD (used with either gelatin or PU), and PU modified by gelatin and CBD-RGD all demonstrated higher EC affinity after freeze-drying and gamma irradiation (2.5 Mrad). The positive cellular effect remained after storage. Based on these results, freeze-drying followed by gamma irradiation at 2.5 Mrad is a proper way to process and store these vascular grafts.en_US
dc.language.isoen_USzh_TW
dc.relationBio-Medical Materials and Engineeringen_US
dc.relation.ispartofseriesBio-Medical Materials and Engineering, Volume 16, Issue 6, Page(s) 397-404.en_US
dc.subjectpolyurethaneen_US
dc.subjectgelatinen_US
dc.subjectRGD-containing proteinen_US
dc.subjectgamma irradiationen_US
dc.subjectendothelial cellsen_US
dc.subjectgelatin gelsen_US
dc.subjectradiationen_US
dc.subjectpeptidesen_US
dc.subjectadhesionen_US
dc.subjectsurfacesen_US
dc.subjectbeamen_US
dc.titleEndothelial cell attachment to the gamma irradiated small diameter polyurethane vascular graftsen_US
dc.typeJournal Articlezh_TW
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