請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/41359
標題: Fabrication and evaluation of microgrooved polymers as peripheral nerve conduits
作者: Hsu, S.H.
徐善慧
Lu, P.S.
Ni, H.C.
Su, C.H.
關鍵字: microgrooves
cell alignment
chitosan
poly(D,L-lactide)
neurotrophic
factors
schwann-cell growth
neurotrophic factor
chitosan membranes
regeneration
alignment
guidance
grafts
topography
mechanisms
migration
期刊/報告no:: Biomedical Microdevices, Volume 9, Issue 5, Page(s) 665-674.
摘要: Cell alignment plays an important role in the repair of damaged peripheral nerves. The aligned Schwann cells could direct the axonal outgrowth during nerve reconstruction. One way of aligning Schwann cells is to use surface grooves in micrometric dimensions. In this study, microgrooves on chitosan or polyd,(D, L-lactide) (PLA) were fabricated and the behaviors of Schwann cells and glial cell line C6 on these surfaces were examined. It was found that Schwann cells and C6 cells could be successfully aligned by the microgrooves, and express the genes related to the production of neurotrophic factors. The polymer conduits with microgrooves on the inner surface were implanted in rats to repair the damaged sciatic nerve. The microgrooved conduits were demonstrated to enhance peripheral nerve regeneration as compared to the smooth conduits.
URI: http://hdl.handle.net/11455/41359
ISSN: 1387-2176
文章連結: http://dx.doi.org/10.1007/s10544-007-9068-0
顯示於類別:化學工程學系所

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