Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/41442
DC FieldValueLanguage
dc.contributor.authorHsu, S.en_US
dc.contributor.author徐善慧zh_TW
dc.contributor.authorHuang, T.B.en_US
dc.date2000zh_TW
dc.date.accessioned2014-06-06T08:05:32Z-
dc.date.available2014-06-06T08:05:32Z-
dc.identifier.issn0141-3910zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/41442-
dc.description.abstractSusceptibility of poly(ether)urethanes (PEU) to hydrolytic degradation by enzymes after a limited exposure to free radicals was investigated. Two PEU, one chain extended with 1,4-butanediol and the other chain extended with 2-butene-1,4-diol, were used as model polymers. Each material was subjected to treatments including oxidative, enzymatic (with papain), and oxidative followed by enzymatic treatment. The degradative effect on surfaces was examined by optical microscopy, attenuated total reflectance infrared spectroscopy as well as XPS. It was found that enzymatic degradation occurred only after certain amount of oxidative change had been initiated. This was probably associated with enzyme adsorption on surfaces pre-exposed to oxidation. The extent of overall degradation was strongly influenced by the oxidation stability of the materials. PEU chain extended with 2-butene-1,4-diol was more resistant to oxidation, and hence less susceptible to enzymatic degradation. It was concluded that exposure of PEU to oxidative pretreatment increased its susceptibility to hydrolysis by enzymes, and that oxidation followed by enzymatic attack could be the biodegradation mechanism of PEU in vivo. (C) 1999 Elsevier Science Ltd. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationPolymer Degradation and Stabilityen_US
dc.relation.ispartofseriesPolymer Degradation and Stability, Volume 67, Issue 1, Page(s) 171-178.en_US
dc.relation.urihttp://dx.doi.org/10.1016/s0141-3910(99)00110-xen_US
dc.subjectsubcutaneous implantationen_US
dc.subjectmediated fragmentationen_US
dc.subjectsegment chemistryen_US
dc.subjecturethane urea)en_US
dc.subjectinvitroen_US
dc.subjectpolyurethanesen_US
dc.subjectbiostabilityen_US
dc.subjectpolyetherurethaneen_US
dc.subjectbiodegradationen_US
dc.subjectelastomeren_US
dc.titleThe susceptibility of poly(ether)urethanes to enzymatic degradation after oxidative pretreatmenten_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/s0141-3910(99)00110-xzh_TW
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