請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/41615
標題: Biocompatibility of poly(epsilon-caprolactone)/poly(ethylene glycol) diblock copolymers with nanophase separation
作者: Hsu, S.H.
徐善慧
Tang, C.M.
Lin, C.C.
林助傑
關鍵字: PCL/PEG diblock copolymer
microphase separation
nanotopography
cell
responses inflammation
platelet activation
protein adsorption
focal adhesions
surfaces
nanotopography
cells
topography
density
期刊/報告no:: Biomaterials, Volume 25, Issue 25, Page(s) 5593-5601.
摘要: In this study, we prepared diblock copolymers of poly(epsilon-caprolactone) (PCL) and poly(ethylene glycol) (PEG) by aluminum alkoxide catalysts. The biological responses to the spin cast surface of different PCL/PEG diblock copolymers were investigated in vitro. Our results showed that Surface hydrophilicity improved with the increased PEG segments in diblock copolymers and that bacteria adhesion was inhibited by increased PEG contents. PCL-PEG 23:77 showed nanotopography on the surface. The number of adhered endothelial cells, platelets and monocytes on diblock copolymer surfaces was inhibited in PCL-PEG 77:23 and enhanced in PCL-PEG 23:77. Nevertheless, the platelet and monocyte activation on PCL-PEG 23:77 was reduced. PCL-PEG 23:77 had better cellular response as well as lower degree of platelet and monocyte activation. The current study was the first one to demonstrate that surface nanotopography could influence not only cell adhesion and growth but also platelet and monocyte activation. (C) 2004 Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/41615
ISSN: 0142-9612
文章連結: http://dx.doi.org/10.1016/j.biomaterials.2004.01.061
顯示於類別:化學工程學系所

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