請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/42067
標題: Preparation of highly pure zeaxanthin particles from sea water-cultivated microalgae using supercritical anti-solvent recrystallization
作者: Chen, Chao-Rui
Hong, Siang-En
Wang, Yuan-Chuen
Hsu, Shih-Lan
Hsiang, Daina
Chieh-Ming, J.Chang
關鍵字: Supercritical anti-solvent
Column partition chromatography
Microalgae
Nannochloropsis oculata
Zeaxanthin
摘要: Xanthophylls, including zeaxanthin, are considered dietary supplements with a potentially positive impact on age-related macular degeneration. Using pilot-scale column fractionation coupled with supercritical anti-solvent (SAS) recrystallization, highly pure zeaxanthin particulates were prepared from ultrasonic extracts of the microalgae, Nannochloropsis oculata, grown in sea water. Column partition chromatography increased the concentration of zeaxanthin from 36.2 mg/g of the ultrasonic extracts to 425.6 mg/g of the collected column fractions. A response surface methodology was systematically designed for the SAS process by changing feed concentration, CO2 flow rate and anti-solvent pressure. Zeaxanthin-rich particles with a purity of 84.2% and a recovery of 85.3% were produced using supercritical anti-solvent recrystallization from the column eluate at a feed concentration of 1.5 mg/mL, CO2 flow rate of 48.6 g/min and pressure of 135 bar.
URI: http://hdl.handle.net/11455/42067
ISSN: 0960-8524
文章連結: http://dx.doi.org/10.1016/j.biortech.2011.11.083
顯示於類別:化學工程學系所

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