Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/43295
標題: The interactive effect of exercise and immunosuppressant cyclosporin A on immune function in mice
作者: Ko, M.H.
巫錦霖
Chang, C.K.
Wu, C.L.
Hou, Y.C.
Hong, W.
Fang, S.H.
關鍵字: Cyclosporine
exercise
immune response
Type I helper T
Type II helper
T cytokines
interferon-gamma
nitric-oxide
rheumatoid-arthritis
long-term
responses
efficacy
moderate
disease
stress
humans
期刊/報告no:: Journal of Sports Sciences, Volume 28, Issue 9, Page(s) 967-973.
摘要: Cyclosporin A (CsA) is an effective immunosuppressive agent and exerts its actions by interfering with the activation of T cells. There is growing evidence that regular exercise improves immune function. However, the effects of exercise on immune functions in patients taking CsA are unclear. Here, we examine the interactive effects of CsA administration and regular exercise on immune function in mice. Forty-eight BALB/c mice were randomly assigned to one of six groups with eight mice per group: 0-Ex (no CsA/no exercise), 0+Ex (no CsA+exercise), 10-Ex (10mg center dot kg-1 center dot day-1 CsA/no exercise), 10+Ex (10mg center dot kg-1 center dot day-1 CsA+exercise), 20-Ex (20mg center dot kg-1 center dot day-1 CsA/no exercise), and 20+Ex (20mg center dot kg-1 center dot day-1 CsA+exercise). The three exercise groups were trained for 8 weeks, three times a week, at approximately 75% maximum oxygen uptake ([Vdot]O2max). Nitric oxide and interferon-gamma secretions by mitogen-activated macrophages and spleen cells, respectively, were higher in exercise groups than in non-exercise groups receiving the same doses of CsA. The results of this study indicate that regular exercise may enhance Type I helper T cell functions in mice receiving 10 or 20mg center dot kg-1 center dot day-1 CsA. Our results demonstrate that moderate regular exercise modulates the immune function of CsA-treated mice. However, whether this exercise-induced immunomodulatory effect is beneficial or detrimental to CsA-treated patients needs to be clarified.
URI: http://hdl.handle.net/11455/43295
ISSN: 0264-0414
文章連結: http://dx.doi.org/10.1080/02640414.2010.481306
Appears in Collections:運動與健康管理研究所

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