Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/43295
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dc.contributor.authorKo, M.H.en_US
dc.contributor.author巫錦霖zh_TW
dc.contributor.authorChang, C.K.en_US
dc.contributor.authorWu, C.L.en_US
dc.contributor.authorHou, Y.C.en_US
dc.contributor.authorHong, W.en_US
dc.contributor.authorFang, S.H.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T08:10:32Z-
dc.date.available2014-06-06T08:10:32Z-
dc.identifier.issn0264-0414zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/43295-
dc.description.abstractCyclosporin A (CsA) is an effective immunosuppressive agent and exerts its actions by interfering with the activation of T cells. There is growing evidence that regular exercise improves immune function. However, the effects of exercise on immune functions in patients taking CsA are unclear. Here, we examine the interactive effects of CsA administration and regular exercise on immune function in mice. Forty-eight BALB/c mice were randomly assigned to one of six groups with eight mice per group: 0-Ex (no CsA/no exercise), 0+Ex (no CsA+exercise), 10-Ex (10mg center dot kg-1 center dot day-1 CsA/no exercise), 10+Ex (10mg center dot kg-1 center dot day-1 CsA+exercise), 20-Ex (20mg center dot kg-1 center dot day-1 CsA/no exercise), and 20+Ex (20mg center dot kg-1 center dot day-1 CsA+exercise). The three exercise groups were trained for 8 weeks, three times a week, at approximately 75% maximum oxygen uptake ([Vdot]O2max). Nitric oxide and interferon-gamma secretions by mitogen-activated macrophages and spleen cells, respectively, were higher in exercise groups than in non-exercise groups receiving the same doses of CsA. The results of this study indicate that regular exercise may enhance Type I helper T cell functions in mice receiving 10 or 20mg center dot kg-1 center dot day-1 CsA. Our results demonstrate that moderate regular exercise modulates the immune function of CsA-treated mice. However, whether this exercise-induced immunomodulatory effect is beneficial or detrimental to CsA-treated patients needs to be clarified.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Sports Sciencesen_US
dc.relation.ispartofseriesJournal of Sports Sciences, Volume 28, Issue 9, Page(s) 967-973.en_US
dc.relation.urihttp://dx.doi.org/10.1080/02640414.2010.481306en_US
dc.subjectCyclosporineen_US
dc.subjectexerciseen_US
dc.subjectimmune responseen_US
dc.subjectType I helper Ten_US
dc.subjectType II helperen_US
dc.subjectT cytokinesen_US
dc.subjectinterferon-gammaen_US
dc.subjectnitric-oxideen_US
dc.subjectrheumatoid-arthritisen_US
dc.subjectlong-termen_US
dc.subjectresponsesen_US
dc.subjectefficacyen_US
dc.subjectmoderateen_US
dc.subjectdiseaseen_US
dc.subjectstressen_US
dc.subjecthumansen_US
dc.titleThe interactive effect of exercise and immunosuppressant cyclosporin A on immune function in miceen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1080/02640414.2010.481306zh_TW
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