Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/43734
標題: Psoralea corylifolia extract ameliorates experimental osteoporosis in ovariectomized rats
作者: Tsai, M.H.
蔡孟勳
Huang, G.S.
Hung, Y.C.
Bin, L.
Liao, L.T.
Lin, L.W.
關鍵字: Psoralea corylifolia
ovariectomized
osteoporosis
replacement therapy
bone metabolism
estrogen
density
guidelines
women
age
期刊/報告no:: American Journal of Chinese Medicine, Volume 35, Issue 4, Page(s) 669-680.
摘要: We evaluated the protective effect of Psoralea corylifolia L. (PCL) extract on the ovariectomized (OVX) rat model. The biochemical markers of bone turnover, calcium metabolism, and calcium balance were examined. PCL extract (25 mg or 50 mg/kg body weight/day) was orally administrated to OVX rats for 3 months. PCL extract did not alter weight gain or uterus weight in OVX rats. PCL extract significantly increased serum Ca (calcium) levels (p < 0.05, vs. OVX group) as well as decreased urinary Ca excretion (p < 0.05, vs. OVX group) in OVX rats. The upregulation of serum osteocalcin level by ovariectomy was suppressed by treatment with PCL extract in rats (p < 0.05, vs. OVX group). PCL extract increased bone mineral density at 50 mg/kg body weight/day in OVX rats (p < 0.05, vs. OVX group). Our results indicate that orally administrated PCL extract can decrease urinary calcium excretion and decrease serum osteocalcin in OVX rats, resulting in positive effects on bone mineral density as well as bone formation. In conclusion, our studies showed that PCL might be a potential candidate for treatment of postmenopausal osteoporosis.
URI: http://hdl.handle.net/11455/43734
ISSN: 0192-415X
文章連結: http://dx.doi.org/10.1142/s0192415x07005168
Appears in Collections:資訊管理學系

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