Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/45153
標題: Alteration of endogenous antioxidant enzymes in naturally occurring hypertrophic cardiomyopathy
作者: Lin, C.S.
黃三元
Liu, C.Y.
Sun, Y.L.
Chang, L.C.
Chiu, Y.T.
Huang, S.Y.
Lin, J.H.
Yang, P.C.
Chu, R.M.
Huang, M.C.
Mao, S.J.T.
黃木秋
關鍵字: hypertrophic cardiomyopathy
mitochondria
oxidative stress
free
radicals
Cu,Zn-superoxide dismutase
Mn-superoxide dismutase
catalase
age-related-changes
superoxide-dismutase
glutathione-peroxidase
hydrogen-peroxide
myocardial-ischemia
oxidative stress
human-disease
pigs
catalase
heart
期刊/報告no:: Biochemistry and Molecular Biology International, Volume 43, Issue 6, Page(s) 1253-1263.
摘要: We have recently developed a porcine model with naturally occurring hypertrophic cardiomyopathy (HCM). Similar to humans, occluded intramural coronary artery and damaged mitochondria are frequently observed in these animals in which the disease is thought to be associated with the local ischemia of myocardium. In view of antioxidant functions involved in the ischemic injury, we measured the expression of endogenous antioxidant enzymes in the tissues with and without HCM. The results showed a significant increase of Cu,Zn-superoxide dismutase (SOD), but not Mn-SOD, and decrease of catalase (CAT) activities in the various areas of HCM hearts. It was demonstrated that SOD/CAT ratios in the HCM hearts were significantly higher than those in normals and were found to be dramatically correlated with the severity of cardiac hypertrophy. The altered SOD/CAT ratio was also consistent with increase in lipid damage. We hypothesize that the elevated SOD combined with an inadequate amount of H2O2 scavenging enzyme may lead HCM heart at oxidative stress risk. However, the pathogenic role of imbalanced antioxidant enzyme needs to be further explored.
URI: http://hdl.handle.net/11455/45153
ISSN: 1039-9712
Appears in Collections:動物科學系

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