Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/46022
標題: A novel guanylyl cyclase receptor, BdmGC-1, is highly expressed during the development of the oriental fruit fly Bactrocera dorsalis (Hendel)
作者: Chang, J.C.
路光暉
Yang, R.B.
Chen, Y.H.
Lu, K.H.
關鍵字: cGMP
guanylyl cyclase
receptor
glycoprotein
Bactrocera dorsalis
natriuretic-peptide receptor
manduca-sexta
nitric-oxide
eclosion
hormone
cyclic-gmp
sensory neurons
nervous-system
alpha-subunit
beta-subunit
identification
期刊/報告no:: Insect Molecular Biology, Volume 15, Issue 1, Page(s) 69-77.
摘要: A novel receptor guanylyl cyclase (GC) has been identified from the oriental fruit fly Bactrocera dorsalis (Hendel) and has been designated BdmGC-1. Protein domain analysis revealed that BdmGC-1 possesses a characteristic domain organization similar to all known receptor GCs but with a unique carboxyl-terminal extension. When overexpressed in 293T cells, BdmGC-1 manifests as a cell-surface glycoprotein with a marked cGMP-generating activity but is unresponsive to all ligands known to activate mammalian receptor GCs. BdmGC-1 mRNAs were highly expressed during development but had low or no expression in adult tissues. On the basis of its unique sequence and distinct developmental expression pattern, BdmGC-1 represents a novel receptor GC that may play a critical role during the development of B. dorsalis.
URI: http://hdl.handle.net/11455/46022
ISSN: 0962-1075
文章連結: http://dx.doi.org/10.1111/j.1365-2583.2006.00609.x
Appears in Collections:昆蟲學系

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