請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/46023
標題: Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis
作者: Chen, K.M.
路光暉
Lee, H.H.
Lu, K.H.
Tseng, Y.K.
Hsu, L.S.
Chou, H.L.
Lai, S.C.
關鍵字: Angiostrongylus cantonensis
Purkinje cells
MMP-9
GM6001
matrix metalloproteinases
cerebrospinal-fluid
tissue inhibitors
nervous-system
gelatinase-b
eosinophils
identification
expression
sclerosis
infection
期刊/報告no:: International Journal for Parasitology, Volume 34, Issue 10, Page(s) 1147-1156.
摘要: Angiostrongylosis is a neurological disorder caused by invasion of the central nervous system by developing larvae of Angiostrongylus cantonensis. Purkinje cells in infected mouse cerebellums are small and irregular with degenerative atrophy or partial loss. Ultrastructural changes in degenerative cells included enlarged vacuolar structures and swollen mitochondria within the cytoplasm. The matrix metalloproteinase-9 mRNA which is low in normal cerebellums was expressed in A. cantonensis-infected mice cerebellum prior to Purkinje cell degeneration. Matrix metalloproteinase-9 protein level and enzyme activity increased when the Purkinje cells appeared degenerated. Using immunohistochemistry, matrix metalloproteinase-9 was localised within degenerative Purkinje cells. In addition, when the specific matrix metalloproteinase inhibitor, GM6001, was added, matrix metalloproteinase-9 enzyme activity was reduced by 41.6%. The numbers of degenerative Purkinje cells increased significantly upon establishment of infection but subsided upon inhibition. These results suggested that the expression of matrix metalloproteinase-9 may be associated with degeneration of Purkinje cells in mouse cerebellum infected by A. cantonensis. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/46023
ISSN: 0020-7519
文章連結: http://dx.doi.org/10.1016/j.ijpara.2004.07.004
顯示於類別:昆蟲學系

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