請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/46024
標題: Evaluating antioxidative activities of amino acid substitutions on mastoparan-B
作者: Yang, M.J.
路光暉
Lin, W.Y.
Lu, K.H.
Tu, W.C.
關鍵字: Antioxidative activity
Mastoparan-B
Structure-activity relationship
Substitution
antimicrobial peptides
cells
analogs
proteins
capacity
venom
ca2+
期刊/報告no:: Peptides, Volume 32, Issue 10, Page(s) 2037-2043.
摘要: Mastoparan-B is a peptide toxin isolated from the venom of Vespa basalis, the most dangerous hornet found in Taiwan. This study is aimed to evaluate the antioxidative activities of several amino acid substitutions on MP-B, and examined the influences of mast cell degranulation and hemolytic activities in parallel with antioxidative activities. The correlations between the biological function and amino acid sequence were assessed. Our study shows original MP-B is a valuable antioxidant at low concentration in competing with nitric-oxide for oxygen molecules and possesses good antioxidative enzyme activities resembled to superoxidase dismutase and glutathione peroxidase. And there are no predominant rates of mast cell degranulation and hemolytic effects in such condition. With proper substitutions, the reducing power, DPPH scavenging activity and glutathione reductase-like enzyme activity of MP-B can increase clearly. The results demonstrate that MP-B analogs are very potential to be applicable antioxidants for other antioxidative usages. (C) 2011 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/46024
ISSN: 0196-9781
文章連結: http://dx.doi.org/10.1016/j.peptides.2011.08.026
顯示於類別:昆蟲學系

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