請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/46186
標題: Strategies and mechanisms of plant virus resistance
作者: Lin, S.S.
葉錫東
Henriques, R.
Wu, H.W.
Niu, Q.W.
Yeh, S.D.
Chua, N.H.
關鍵字: tobacco-mosaic-virus
tobamovirus cross-protection
pathogen-derived
resistance
protein-mediated resistance
helper component-protease
dependent rna-polymerase
dicer-like proteins
viral coat protein
short
hairpin rnas
transgenic plants
期刊/報告no:: Plant Biotechnology Reports, Volume 1, Issue 3, Page(s) 125-134.
摘要: Virus-induced diseases are responsible for major crop losses worldwide. A better understanding of plant defense mechanisms would lead to the development of novel strategies for effective plant protection. Early protein-based approaches relied mostly on the expression of transgenic coat protein (CP) to block the progression of the virus infectious process. Other strategies exploit the plant's innate defense mechanisms to combat invading viral pathogens. For example, the RNA-based resistance makes use of the plant post-transcriptional gene silencing (PTGS) mechanism to degrade viral RNAs. In cross-protection the prior inoculation with a mild viral strain confers resistance against a severe strain. Although the molecular detail of cross-protection is not fully understood, it is likely to be comprised of both protein-and RNA- based mechanisms, as well as some other unknown processes. In this review article we compare the benefits and challenges of these different viral-resistance approaches. Furthermore, we discuss the development of a new approach based on the plant's miRNA pathway. Artificial miRNAs with sequences complementary to viral sequences have been successfully used to generate virus resistance. This novel anti-viral strategy, which has the advantage of reducing possible bio-safety risks associated with protein-and RNA based strategies, is a first step toward designing environmentally friendly virus resistance in transgenic crops.
URI: http://hdl.handle.net/11455/46186
ISSN: 1863-5466
文章連結: http://dx.doi.org/10.1007/s11816-007-0021-8
顯示於類別:植物病理學系

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