Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/50306
標題: A conserved transcriptional regulator is required for RNA-directed DNA methylation and plant development
作者: He, X.J.
王國祥
Hsu, Y.F.
Zhu, S.H.
Liu, H.L.
Pontes, O.
Zhu, J.H.
Cui, X.P.
Wang, C.S.
Zhu, J.K.
關鍵字: RDM4
siRNA
transcriptional gene silencing
Pol II
Pol V
polymerase-ii
arabidopsis-thaliana
pol-iv
protein
glycosylase/lyase
pathways
subunit
ros1
期刊/報告no:: Genes & Development, Volume 23, Issue 23, Page(s) 2717-2722.
摘要: RNA-directed DNA methylation (RdDM) is a conserved mechanism for epigenetic silencing of transposons and other repetitive elements. We report that the rdm4 (RNA-directed DNA Methylation4) mutation not only impairs RdDM, but also causes pleiotropic developmental defects in Arabidopsis. Both RNA polymerase II (Pol II)- and Pol V-dependent transcripts are affected in the rdm4 mutant. RDM4 encodes a novel protein that is conserved from yeast to humans and interacts with Pol II and Pol V in plants. Our results suggest that RDM4 functions in epigenetic regulation and plant development by serving as a transcriptional regulator for RNA Pol V and Pol II, respectively.
URI: http://hdl.handle.net/11455/50306
ISSN: 0890-9369
文章連結: http://dx.doi.org/10.1101/gad.1851809
Appears in Collections:生物科技學研究所

文件中的檔案:

取得全文請前往華藝線上圖書館



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.