Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/5898
DC FieldValueLanguage
dc.contributor林伯雄zh_TW
dc.contributorPo-Hsiung Linen_US
dc.contributor.author葛茂輝zh_TW
dc.contributor.authorKo, Mao-Huien_US
dc.contributor.other環境工程學系所zh_TW
dc.date2012en_US
dc.date.accessioned2014-06-06T06:36:00Z-
dc.date.available2014-06-06T06:36:00Z-
dc.identifierU0005-1607201217262700en_US
dc.identifier.citation參考文獻 魏子翰 (2009)同步分析人類血清白蛋白中萘及雌性激素醌類代謝物之蛋白質胼合物。國立中興大學環境工程研究所碩士論文,台灣台中。 林慶全 (2011)運用血清白蛋白為生物指標探討體內累積隻雌性激素-3,4-苯醌代謝物作為乳癌風險預測指標之研究。國立中興大學環境工程研究所碩士論文,台灣台中。 阮常新 (2012)探討乳癌病人之雌性激素生物活化及核酸修補之基因多型性與核酸破壞作用之相關性。國立中興大學環境工程研究所碩士論文,台灣台中。 Ahsan, H., Chen, Y., Whittemore, A.S., Kibriya, M.G., Gurvich, I., Senie, R.T., Santella, R.M., 2004. A family-based genetic association study of variants in estrogen-metabolism genes COMT and CYP1B1 and breast cancer risk. Breast Cancer Res Treat 85, 121-131. Bagchi, M., Balmoori, J., Ye, X., Bagchi, D., Ray, S.D., Stohs, S.J., 2001. Protective effect of melatonin on naphthalene-induced oxidative stress and DNA damage in cultured macrophage J774A.1 cells. Mol Cell Biochem 221, 49-55. Bell, D.A., Taylor, J.A., Paulson, D.F., Robertson, C.N., Mohler, J.L., Lucier, G.W., 1993. Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 85, 1159-1164. Boffetta, P., Jourenkova, N., Gustavsson, P., 1997. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control 8, 444-472. Boyland, E., Chasseaud, L.F., 1969. The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis. Adv Enzymol Relat Areas Mol Biol 32, 173-219. Burdick, A.D., Davis, J.W., 2nd, Liu, K.J., Hudson, L.G., Shi, H., Monske, M.L., Burchiel, S.W., 2003. Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells. Cancer Res 63, 7825-7833. Butterworth, M., Lau, S.S., Monks, T.J., 1996. 17 beta-estradiol metabolism by hamster hepatic microsomes: comparison of catechol estrogen O-methylation with catechol estrogen oxidation and glutathione conjugation. Chem Res Toxicol 9, 793-799. Cao, K., Stack, D.E., Ramanathan, R., Gross, M.L., Rogan, E.G., Cavalieri, E.L., 1998. Synthesis and structure elucidation of estrogen quinones conjugated with cysteine, N-acetylcysteine, and glutathione. Chem Res Toxicol 11, 909-916. Cavalieri, E., Chakravarti, D., Guttenplan, J., Hart, E., Ingle, J., Jankowiak, R., Muti, P., Rogan, E., Russo, J., Santen, R., Sutter, T., 2006. Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention. Biochim Biophys Acta 1766, 63-78. Chen, D.R., Chen, S.T., Wang, T.W., Tsai, C.H., Wei, H.H., Chen, G.J., Yang, T.C., Lin, C., Lin, P.H., 2011. Characterization of estrogen quinone-derived protein adducts and their identification in human serum albumin derived from breast cancer patients and healthy controls. Toxicol Lett 202, 244-252. Christofolini, D.M., Teles, J.S., Vilarino, F.L., Andre, G.M., Bianco, B., Barbosa, C.P., 2011. COMT polymorphism and the risk of endometriosis-related infertility. Gynecol Endocrinol 27, 1099-1102. Chung, M.K., Riby, J., Li, H., Iavarone, A.T., Williams, E.R., Zheng, Y., Rappaport, S.M., 2010. A sandwich enzyme-linked immunosorbent assay for adducts of polycyclic aromatic hydrocarbons with human serum albumin. Anal Biochem 400, 123-129. Clemons, M., Goss, P., 2001. Estrogen and the risk of breast cancer. N Engl J Med 344, 276-285. Darabi, H., Czene, K., Wedren, S., Li, Y., Liu, J., Hall, P., Humphreys, K., 2011. Genetic variation in the androgen estrogen conversion pathway in relation to breast cancer prognosticators. Breast Cancer Res Treat 127, 503-509. de Jong, M.M., Nolte, I.M., te Meerman, G.J., van der Graaf, W.T., Oosterwijk, J.C., Kleibeuker, J.H., Schaapveld, M., de Vries, E.G., 2002. Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility. J Med Genet 39, 225-242. Delort, L., Satih, S., Kwiatkowski, F., Bignon, Y.J., Bernard-Gallon, D.J., 2010. Evaluation of breast cancer risk in a multigenic model including low penetrance genes involved in xenobiotic and estrogen metabolisms. Nutr Cancer 62, 243-251. Denison, M.S., Nagy, S.R., 2003. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu Rev Pharmacol Toxicol 43, 309-334. Deziel, N.C., Buckley, T.J., Sinha, R., Abubaker, S., Platz, E.A., Strickland, P.T., 2012. Comparability and repeatability of methods for estimating the dietary intake of the heterocyclic amine contaminant 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP). Food Addit Contam Part A Chem Anal Control Expo Risk Assess. Dingley, K.H., Curtis, K.D., Nowell, S., Felton, J.S., Lang, N.P., Turteltaub, K.W., 1999. DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Cancer Epidemiol Biomarkers Prev 8, 507-512. Dinkova-Kostova, A.T., Talalay, P., 2010. NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch Biochem Biophys 501, 116-123. Eaton, D.L., Bammler, T.K., 1999. Concise review of the glutathione S-transferases and their significance to toxicology. Toxicol Sci 49, 156-164. Ehrenberg, L., Granath, F., Tornqvist, M., 1996. Macromolecule adducts as biomarkers of exposure to environmental mutagens in human populations. Environ Health Perspect 104 Suppl 3, 423-428. Fagerholm, R., Hofstetter, B., Tommiska, J., Aaltonen, K., Vrtel, R., Syrjakoski, K., Kallioniemi, A., Kilpivaara, O., Mannermaa, A., Kosma, V.M., Uusitupa, M., Eskelinen, M., Kataja, V., Aittomaki, K., von Smitten, K., Heikkila, P., Lukas, J., Holli, K., Bartkova, J., Blomqvist, C., Bartek, J., Nevanlinna, H., 2008. NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nat Genet 40, 844-853. Gammon, M.D., Santella, R.M., 2008. PAH, genetic susceptibility and breast cancer risk: an update from the Long Island Breast Cancer Study Project. Eur J Cancer 44, 636-640. Garte, S., Gaspari, L., Alexandrie, A.K., Ambrosone, C., Autrup, H., Autrup, J.L., Baranova, H., Bathum, L., Benhamou, S., Boffetta, P., Bouchardy, C., Breskvar, K., Brockmoller, J., Cascorbi, I., Clapper, M.L., Coutelle, C., Daly, A., Dell''Omo, M., Dolzan, V., Dresler, C.M., Fryer, A., Haugen, A., Hein, D.W., Hildesheim, A., Hirvonen, A., Hsieh, L.L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Kihara, M., Kiyohara, C., Kremers, P., Lazarus, P., Le Marchand, L., Lechner, M.C., van Lieshout, E.M., London, S., Manni, J.J., Maugard, C.M., Morita, S., Nazar-Stewart, V., Noda, K., Oda, Y., Parl, F.F., Pastorelli, R., Persson, I., Peters, W.H., Rannug, A., Rebbeck, T., Risch, A., Roelandt, L., Romkes, M., Ryberg, D., Salagovic, J., Schoket, B., Seidegard, J., Shields, P.G., Sim, E., Sinnet, D., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M.C., Taioli, E., 2001. Metabolic gene polymorphism frequencies in control populations. Cancer Epidemiol Biomarkers Prev 10, 1239-1248. Ghosh, A., Choudhury, A., Das, A., Chatterjee, N.S., Das, T., Chowdhury, R., Panda, K., Banerjee, R., Chatterjee, I.B., 2012. Cigarette smoke induces p-benzoquinone-albumin adduct in blood serum: Implications on structure and ligand binding properties. Toxicology 292, 78-89. Hachey, D.L., Dawling, S., Roodi, N., Parl, F.F., 2003. Sequential action of phase I and II enzymes cytochrome p450 1B1 and glutathione S-transferase P1 in mammary estrogen metabolism. Cancer Res 63, 8492-8499. Haritash, A.K., Kaushik, C.P., 2009. Biodegradation aspects of polycyclic aromatic hydrocarbons (PAHs): a review. J Hazard Mater 169, 1-15. Harris, H.R., Willett, W.C., Terry, K.L., Michels, K.B., 2011. Body fat distribution and risk of premenopausal breast cancer in the Nurses'' Health Study II. J Natl Cancer Inst 103, 273-278. Hayes, J.D., Flanagan, J.U., Jowsey, I.R., 2005. Glutathione transferases. Annu Rev Pharmacol Toxicol 45, 51-88. Helzlsouer, K.J., Selmin, O., Huang, H.Y., Strickland, P.T., Hoffman, S., Alberg, A.J., Watson, M., Comstock, G.W., Bell, D., 1998. Association between glutathione S-transferase M1, P1, and T1 genetic polymorphisms and development of breast cancer. J Natl Cancer Inst 90, 512-518. Hirvonen, A., 1995. Genetic factors in individual responses to environmental exposures. J Occup Environ Med 37, 37-43. Huang, C.S., Chern, H.D., Chang, K.J., Cheng, C.W., Hsu, S.M., Shen, C.Y., 1999. Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes CYP17, CYP1A1, and COMT: a multigenic study on cancer susceptibility. Cancer Res 59, 4870-4875. Huang, C.S., Lin, C.H., Lu, Y.S., Shen, C.Y., 2010. Unique features of breast cancer in Asian women--breast cancer in Taiwan as an example. J Steroid Biochem Mol Biol 118, 300-303. Jamshidi, M., Bartkova, J., Greco, D., Tommiska, J., Fagerholm, R., Aittomaki, K., Mattson, J., Villman, K., Vrtel, R., Lukas, J., Heikkila, P., Blomqvist, C., Bartek, J., Nevanlinna, H., 2012. NQO1 expression correlates inversely with NFkappaB activation in human breast cancer. Breast Cancer Res Treat 132, 955-968. Kensler, T.W., Gange, S.J., Egner, P.A., Dolan, P.M., Munoz, A., Groopman, J.D., Rogers, A.E., Roebuck, B.D., 1997. Predictive value of molecular dosimetry: individual versus group effects of oltipraz on aflatoxin-albumin adducts and risk of liver cancer. Cancer Epidemiol Biomarkers Prev 6, 603-610. Key, T.J., Appleby, P.N., Reeves, G.K., Roddam, A., Dorgan, J.F., Longcope, C., Stanczyk, F.Z., Stephenson, H.E., Jr., Falk, R.T., Miller, R., Schatzkin, A., Allen, D.S., Fentiman, I.S., Wang, D.Y., Dowsett, M., Thomas, H.V., Hankinson, S.E., Toniolo, P., Akhmedkhanov, A., Koenig, K., Shore, R.E., Zeleniuch-Jacquotte, A., Berrino, F., Muti, P., Micheli, A., Krogh, V., Sieri, S., Pala, V., Venturelli, E., Secreto, G., Barrett-Connor, E., Laughlin, G.A., Kabuto, M., Akiba, S., Stevens, R.G., Neriishi, K., Land, C.E., Cauley, J.A., Kuller, L.H., Cummings, S.R., Helzlsouer, K.J., Alberg, A.J., Bush, T.L., Comstock, G.W., Gordon, G.B., Miller, S.R., 2003. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst 95, 1218-1226. Key, T.J., Pike, M.C., 1988. The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer. Eur J Cancer Clin Oncol 24, 29-43. Kocabas, N.A., Sardas, S., Cholerton, S., Daly, A.K., Karakaya, A.E., 2002. Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population. Arch Toxicol 76, 643-649. Koh, W.P., Nelson, H.H., Yuan, J.M., Van den Berg, D., Jin, A., Wang, R., Yu, M.C., 2011. Glutathione S-transferase (GST) gene polymorphisms, cigarette smoking and colorectal cancer risk among Chinese in Singapore. Carcinogenesis 32, 1507-1511. Li, B., Ricordel, I., Schopfer, L.M., Baud, F., Megarbane, B., Nachon, F., Masson, P., Lockridge, O., 2010. Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos. Toxicol Sci 116, 23-31. Lin, P.H., Waidyanatha, S., Pollack, G.M., Rappaport, S.M., 1997. Dosimetry of chlorinated quinone metabolites of pentachlorophenol in the livers of rats and mice based upon measurement of protein adducts. Toxicol Appl Pharmacol 145, 399-408. Lu, S., Wang, Z., Cui, D., Liu, H., Hao, X., 2011. Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects. Breast Cancer Res Treat 125, 253-259. MacMahon, B., Cole, P., Lin, T.M., Lowe, C.R., Mirra, A.P., Ravnihar, B., Salber, E.J., Valaoras, V.G., Yuasa, S., 1970. Age at first birth and breast cancer risk. Bull World Health Organ 43, 209-221. McCoy, L.F., Scholl, P.F., Sutcliffe, A.E., Kieszak, S.M., Powers, C.D., Rogers, H.S., Gong, Y.Y., Groopman, J.D., Wild, C.P., Schleicher, R.L., 2008. Human aflatoxin albumin adducts quantitatively compared by ELISA, HPLC with fluorescence detection, and HPLC with isotope dilution mass spectrometry. Cancer Epidemiol Biomarkers Prev 17, 1653-1657. McPherson, K., Steel, C.M., Dixon, J.M., 2000. ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics. BMJ 321, 624-628. Minelli, C., Granell, R., Newson, R., Rose-Zerilli, M.J., Torrent, M., Ring, S.M., Holloway, J.W., Shaheen, S.O., Henderson, J.A., 2010. Glutathione-S-transferase genes and asthma phenotypes: a Human Genome Epidemiology (HuGE) systematic review and meta-analysis including unpublished data. Int J Epidemiol 39, 539-562. Minghetti, P.P., Ruffner, D.E., Kuang, W.J., Dennison, O.E., Hawkins, J.W., Beattie, W.G., Dugaiczyk, A., 1986. Molecular structure of the human albumin gene is revealed by nucleotide sequence within q11-22 of chromosome 4. J Biol Chem 261, 6747-6757. Mitrunen, K., Hirvonen, A., 2003. Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism. Mutat Res 544, 9-41. Mitrunen, K., Jourenkova, N., Kataja, V., Eskelinen, M., Kosma, V.M., Benhamou, S., Kang, D., Vainio, H., Uusitupa, M., Hirvonen, A., 2001. Polymorphic catechol-O-methyltransferase gene and breast cancer risk. Cancer Epidemiol Biomarkers Prev 10, 635-640. Morimoto, L.M., White, E., Chen, Z., Chlebowski, R.T., Hays, J., Kuller, L., Lopez, A.M., Manson, J., Margolis, K.L., Muti, P.C., Stefanick, M.L., McTiernan, A., 2002. Obesity, body size, and risk of postmenopausal breast cancer: the Women''s Health Initiative (United States). Cancer Causes Control 13, 741-751. Mortensen, A.S., Arukwe, A., 2008. Activation of estrogen receptor signaling by the dioxin-like aryl hydrocarbon receptor agonist, 3,3'',4,4'',5-pentachlorobiphenyl (PCB126) in salmon in vitro system. Toxicol Appl Pharmacol 227, 313-324. Nazar-Stewart, V., Motulsky, A.G., Eaton, D.L., White, E., Hornung, S.K., Leng, Z.T., Stapleton, P., Weiss, N.S., 1993. The glutathione S-transferase mu polymorphism as a marker for susceptibility to lung carcinoma. Cancer Res 53, 2313-2318. Pastore, A., Piemonte, F., Locatelli, M., Lo Russo, A., Gaeta, L.M., Tozzi, G., Federici, G., 2001. Determination of blood total, reduced, and oxidized glutathione in pediatric subjects. Clin Chem 47, 1467-1469. Poirier, M.C., Santella, R.M., Weston, A., 2000. Carcinogen macromolecular adducts and their measurement. Carcinogenesis 21, 353-359. Pompella, A., Visvikis, A., Paolicchi, A., De Tata, V., Casini, A.F., 2003. The changing faces of glutathione, a cellular protagonist. Biochem Pharmacol 66, 1499-1503. Rogan, E.G., Badawi, A.F., Devanesan, P.D., Meza, J.L., Edney, J.A., West, W.W., Higginbotham, S.M., Cavalieri, E.L., 2003. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer. Carcinogenesis 24, 697-702. Romero, A., Martin, M., Oliva, B., de la Torre, J., Furio, V., de la Hoya, M., Garcia-Saenz, J.A., Moreno, A., Roman, J.M., Diaz-Rubio, E., Caldes, T., 2011. Glutathione S-transferase P1 c.313A > G polymorphism could be useful in the prediction of doxorubicin response in breast cancer patients. Ann Oncol. Ross, D., Kepa, J.K., Winski, S.L., Beall, H.D., Anwar, A., Siegel, D., 2000. NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem Biol Interact 129, 77-97. Saeed, M., Higginbotham, S., Gaikwad, N., Chakravarti, D., Rogan, E., Cavalieri, E., 2009. Depurinating naphthalene-DNA adducts in mouse skin related to cancer initiation. Free Radic Biol Med 47, 1075-1081. Safe, S., 2001. Molecular biology of the Ah receptor and its role in carcinogenesis. Toxicol Lett 120, 1-7. Safe, S., Wormke, M., 2003. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chem Res Toxicol 16, 807-816. Safe, S., Wormke, M., Samudio, I., 2000. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. J Mammary Gland Biol Neoplasia 5, 295-306. Scholl, P.F., Groopman, J.D., 2008. Long-term stability of human aflatoxin B1 albumin adducts assessed by isotope dilution mass spectrometry and high-performance liquid chromatography-fluorescence. Cancer Epidemiol Biomarkers Prev 17, 1436-1439. Sergentanis, T.N., Economopoulos, K.P., 2010. Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis. Breast Cancer Res Treat 122, 459-469. Sherman, B.M., Korenman, S.G., 1974. Measurement of serum LH, FSH, estradiol and progesterone in disorders of the human menstrual cycle: the inadequate luteal phase. J Clin Endocrinol Metab 39, 145-149. Shipley, J.M., Waxman, D.J., 2006. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene. Toxicol Appl Pharmacol 213, 87-97. Smith, I.E., Dowsett, M., 2003. Aromatase inhibitors in breast cancer. N Engl J Med 348, 2431-2442. Stoll, B.A., 1994. Breast cancer: the obesity connection. Br J Cancer 69, 799-801. Strange, R.C., Spiteri, M.A., Ramachandran, S., Fryer, A.A., 2001. Glutathione-S-transferase family of enzymes. Mutat Res 482, 21-26. Tang, L., Xu, L., Afriyie-Gyawu, E., Liu, W., Wang, P., Tang, Y., Wang, Z., Huebner, H.J., Ankrah, N.A., Ofori-Adjei, D., Williams, J.H., Wang, J.S., Phillips, T.D., 2009. Aflatoxin-albumin adducts and correlation with decreased serum levels of vitamins A and E in an adult Ghanaian population. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26, 108-118. Tang, L., Yao, S., Till, C., Goodman, P.J., Tangen, C.M., Wu, Y., Kristal, A.R., Platz, E.A., Neuhouser, M.L., Stanczyk, F.Z., Reichardt, J.K., Santella, R.M., Hsing, A., Hoque, A., Lippman, S.M., Thompson, I.M., Ambrosone, C.B., 2011. Repeat polymorphisms in estrogen metabolism genes and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Carcinogenesis 32, 1500-1506. Tornqvist, M., Fred, C., Haglund, J., Helleberg, H., Paulsson, B., Rydberg, P., 2002. Protein adducts: quantitative and qualitative aspects of their formation, analysis and applications. J Chromatogr B Analyt Technol Biomed Life Sci 778, 279-308. Turesky, R.J., Le Marchand, L., 2011. Metabolism and biomarkers of heterocyclic aromatic amines in molecular epidemiology studies: lessons learned from aromatic amines. Chem Res Toxicol 24, 1169-1214. van den Brandt, P.A., Spiegelman, D., Yaun, S.S., Adami, H.O., Beeson, L., Folsom, A.R., Fraser, G., Goldbohm, R.A., Graham, S., Kushi, L., Marshall, J.R., Miller, A.B., Rohan, T., Smith-Warner, S.A., Speizer, F.E., Willett, W.C., Wolk, A., Hunter, D.J., 2000. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 152, 514-527. Vondracek, J., Kozubik, A., Machala, M., 2002. Modulation of estrogen receptor-dependent reporter construct activation and G0/G1-S-phase transition by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells. Toxicol Sci 70, 193-201. Waidyanatha, S., Troester, M.A., Lindstrom, A.B., Rappaport, S.M., 2002. Measurement of hemoglobin and albumin adducts of naphthalene-1,2-oxide, 1,2-naphthoquinone and 1,4-naphthoquinone after administration of naphthalene to F344 rats. Chem Biol Interact 141, 189-210. Wilce, M.C., Parker, M.W., 1994. Structure and function of glutathione S-transferases. Biochim Biophys Acta 1205, 1-18. Yang, X.R., Chang-Claude, J., Goode, E.L., Couch, F.J., Nevanlinna, H., Milne, R.L., Gaudet, M., Schmidt, M.K., Broeks, A., Cox, A., Fasching, P.A., Hein, R., Spurdle, A.B., Blows, F., Driver, K., Flesch-Janys, D., Heinz, J., Sinn, P., Vrieling, A., Heikkinen, T., Aittomaki, K., Heikkila, P., Blomqvist, C., Lissowska, J., Peplonska, B., Chanock, S., Figueroa, J., Brinton, L., Hall, P., Czene, K., Humphreys, K., Darabi, H., Liu, J., Van ''t Veer, L.J., van Leeuwen, F.E., Andrulis, I.L., Glendon, G., Knight, J.A., Mulligan, A.M., O''Malley, F.P., Weerasooriya, N., John, E.M., Beckmann, M.W., Hartmann, A., Weihbrecht, S.B., Wachter, D.L., Jud, S.M., Loehberg, C.R., Baglietto, L., English, D.R., Giles, G.G., McLean, C.A., Severi, G., Lambrechts, D., Vandorpe, T., Weltens, C., Paridaens, R., Smeets, A., Neven, P., Wildiers, H., Wang, X., Olson, J.E., Cafourek, V., Fredericksen, Z., Kosel, M., Vachon, C., Cramp, H.E., Connley, D., Cross, S.S., Balasubramanian, S.P., Reed, M.W., Dork, T., Bremer, M., Meyer, A., Karstens, J.H., Ay, A., Park-Simon, T.W., Hillemanns, P., Arias Perez, J.I., Menendez Rodriguez, P., Zamora, P., Benitez, J., Ko, Y.D., Fischer, H.P., Hamann, U., Pesch, B., Bruning, T., Justenhoven, C., Brauch, H., Eccles, D.M., Tapper, W.J., Gerty, S.M., Sawyer, E.J., Tomlinson, I.P., Jones, A., Kerin, M., Miller, N., McInerney, N., Anton-Culver, H., Ziogas, A., Shen, C.Y., Hsiung, C.N., Wu, P.E., Yang, S.L., Yu, J.C., Chen, S.T., Hsu, G.C., Haiman, C.A., Henderson, B.E., Le Marchand, L., Kolonel, L.N., Lindblom, A., Margolin, S., Jakubowska, A., Lubinski, J., Huzarski, T., Byrski, T., Gorski, B., Gronwald, J., Hooning, M.J., Hollestelle, A., van den Ouweland, A.M., Jager, A., Kriege, M., Tilanus-Linthorst, M.M., Collee, M., Wang-Gohrke, S., Pylkas, K., Jukkola-Vuorinen, A., Mononen, K., Grip, M., Hirvikoski, P., Winqvist, R., Mannermaa, A., Kosma, V.M., Kauppinen, J., Kataja, V., Auvinen, P., Soini, Y., Sironen, R., Bojesen, S.E., Orsted, D.D., Kaur-Knudsen, D., Flyger, H., Nordestgaard, B.G., Holland, H., Chenevix-Trench, G., Manoukian, S., Barile, M., Radice, P., Hankinson, S.E., Hunter, D.J., Tamimi, R., Sangrajrang, S., Brennan, P., McKay, J., Odefrey, F., Gaborieau, V., Devilee, P., Huijts, P.E., Tollenaar, R.A., Seynaeve, C., Dite, G.S., Apicella, C., Hopper, J.L., Hammet, F., Tsimiklis, H., Smith, L.D., Southey, M.C., Humphreys, M.K., Easton, D., Pharoah, P., Sherman, M.E., Garcia-Closas, M., 2011. Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies. J Natl Cancer Inst 103, 250-263. Yang, Y., Sharma, R., Cheng, J.Z., Saini, M.K., Ansari, N.H., Andley, U.P., Awasthi, S., Awasthi, Y.C., 2002. Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2. Invest Ophthalmol Vis Sci 43, 434-445. Yao, L., Yu, X., Yu, L., 2010. Lack of significant association between CYP1A1 T3801C polymorphism and breast cancer risk: a meta-analysis involving 25,087 subjects. Breast Cancer Res Treat 122, 503-507. Zheng, W., Xie, D.W., Jin, F., Cheng, J.R., Dai, Q., Wen, W.Q., Shu, X.O., Gao, Y.T., 2000. Genetic polymorphism of cytochrome P450-1B1 and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 9, 147-150.en_US
dc.identifier.urihttp://hdl.handle.net/11455/5898-
dc.description.abstract本研究目的為測量台灣中部地區女性乳癌病人 (n=67)體內血清白蛋白中雌性激素及萘醌類蛋白質胼合物之背景值及與乳癌風險因子 (年齡、身體質量指標及單一核苷酸基因多型性)間之相關性分析討論。分析結果顯示,乳癌病人 (n=67)體內血清白蛋白E2-2,3-quinone (E2-2,3-Q-4-S-Alb)及 E2-3,4-quinone (E2-3,4-Q-2-S-Alb)所偵測之平均背景值 (標準偏差)分別為393 (263) 及 681 (330) pmol/g。此外,1,2-NPQ-Alb 及1,4-NPQ-Alb 所偵測之平均背景值 (標準偏差)分別為237 (130) 及 78.3 (47.5) pmol/g。1,2-NPQ-Alb 及1,4-NPQ-Alb 具有中度正相關且達顯著差異(r=0.420, p < 0.001)。E2-2,3-Q-4-S-Alb及E2-3,4-Q-2-S-Alb 具有高度正相關且達顯著差異(r=0.707, p < 0.001)。將本研究數據加入先前實驗室所分析之樣本 (n=85)共同討論後發現,在年齡小於50歲且Body Mass Index (BMI)小於27之乳癌病人族群中,其BMI與E2-3,4-Q-2-S-Alb 之背景值呈負相關性 (r=-0.241,p<0.05)。另一方面,乳癌病人(n=152) 中萘醌類蛋白質胼合物1,2-NPQ-Alb與年齡呈現正相關性且達顯著差異 (r=0.266,P<0.001)。而乳癌病人體內之萘醌類蛋白質胼合物1,2-NPQ-Alb之背景值在BMI大於27之族群中高於BMI小於27之族群約30%。另外,本研究結果顯示乳癌患者相較於實驗室先前分析多個之無罹患乳癌樣本,其E2-3,4-Q-2-S-Alb與E2-2,3-Q-4-S-Alb背景值之比值約高出4倍。本研究之結論為乳癌患者體內E2-3,4-Q-2-S-Alb之體內累積劑量為一乳癌風險之預測指標。zh_TW
dc.description.abstractThe aims of this study were to measure the background level of 17B-estradiol (E2) and naphthalene quinone (NPQ)-derived protein adducts in human albumin (Alb) derived from female breast cancer patients (n=67) in central Taiwanese women and to explore the relationships between these adducts with risk factors of breast cancer (Age, Body Mass Index, Single Nucleotide Polymorphism). Results from the analysis indicated that Alb adducts of estrogen quinones, including E2-2,3-quinone (E2-2,3-Q-4-S-Alb) and E2-3,4-quinone (E2-3,4-Q-2-S-Alb) were detected in all subjects (n=67) at average levels were 393 (263) and 681 (330) pmol/g, respectively. In addition, the average levels of cysteinyl adducts of 1,2-NPQ and 1,4-NPQ on human serum albumin were estimated to be 237 (130) and 78.3 (47.5) pmol/g, respectively. Levels of 1,4-NPQ-Alb correlated significantly with those of 1,2-NPQ-Alb (r=0.420, p < 0.001). Similarly, levels of E2-2,3-Q-4-S-Alb correlated significantly with those of E2-3,4-Q-2-S-Alb (r=0.707, p < 0.001). When comparing these data with our previous study (n=85), we noticed that among those breast cancer patients with age under 50 and BMI less than 27, BMI inversely associated with E2-3,4-Q-2-S-Alb (r=-0.241,p<0.05). Additionally, levels of 1,2-NPQ-Alb positively correlated with age (r=0.266,P<0.001). Levels of 1,2-NPQ-Alb in patients with BMI over 27 were 30% higher than patients with BMI under 27. We noteced that the ratio of E2-3,4-Q-Alb and E2-2,3-Q-Alb derived adducts in breast cancer patients were ~4 fold greater than those of controls. This evidence suggests that the cumulative body burden of E2-3,4-Q is a significant indicator of the risk of breast cancer.en_US
dc.description.tableofcontents目錄 摘要 i Abstract ii 縮寫表 (List of Abbreviation) iii 目錄 v 圖目錄 viii 表目錄 xi 第一章 前言 1 1-1 研究緣起 1 1-2 研究目的 1 第二章 文獻回顧 2 2-1 乳癌 2 2-2 乳癌風險因子 3 2-2-1年齡 (Age) 3 2-2-2身體質量指標 (Body Mass Index) 4 2-2-3單一核苷酸基因多型性 (Single Nucleotide Polymorphism) 4 2-3 雌性激素 5 2-3-1 雌性激素代謝 7 2-3-2 雌性激素去活化 10 2-3-2-1 COMT (Catechol-O-Methyltransferase) 10 2-3-2-2 GSTs (Glutathione S-Transferases) 10 2-3-2-3 NQO1 ( NAD(P)H:quinone oxidoreductase 1) 11 2-4 多環芳香族碳氫化合物 12 2-4-1 萘 15 2-5 蛋白質胼合物 (Protein adducts) 16 2-5-1蛋白質胼合物種類 16 2-5-2 生物指標 (Biomarker) 18 2-5-3蛋白質胼合物做為生物指標之動力學模式 19 2-5-4 蛋白質胼合物與分子流行病學之應用 21 第三章實驗架構與設計 23 3-1 實驗架設 23 3-2 研究假設 24 第四章 實驗材料及方法 25 4-1 實驗材料 25 4-1-1 化學品及耗材 25 4-1-2 實驗設備 26 4-2 實驗方法 26 4-2-1 2/4-OHE2-N-acetyl-L-Cysteine Adducts之合成 28 4-2-2 E2-N-acetyl-L-Cysteine Adducts製備 28 4-2-3 E2 - HSA Adducts製備 29 4-2-4利用17β-Estradiol-2, 4, 16, 16, 17-d5製備雌性激素同位素蛋白質胼合物內標準品 30 4-2-5 1,2-NPQ-NAC adduct 之製備 31 4-2-6 1,2-NPQ-HSA adduct 之製備 32 4-2-7 1,4-NPQ-NAC adduct 之製備 32 4-2-8 1,4-NPQ-HSA adduct 之製備 32 4-2-9萘同位素內部標準品之製備 33 4-2-10 TFAA derivatization分析方法 34 4-3氣相層析質譜儀分析條件 35 4-4 HPLC純化E2-NAC Adducts之條件並經由1HNMR確定其結構式 36 4-5透析同位素內標準品 38 4-5-1乳癌患者之血清白蛋白透析 38 4-6彰化基督教醫院乳癌病人之背景資料 39 4-7 統計分析 41 第五章 實驗結果 42 5-1 分析彰化基督教醫院乳癌病人血清白蛋白之雌性激素醌類蛋白質胼合物背景值 42 5-2分析彰化基督教醫院乳癌病人血清白蛋白之萘醌類蛋白質胼合物背景值 42 第六章 討論 46 6-1 彰化基督教醫院乳癌病人之萘及雌性激素醌類蛋白質胼合物同步分析結果 46 6-1-1 同步分析彰化基督教醫院乳癌患者之血清白蛋白胼合物間之相關性 49 6-1-2 同步分析彰化基督教醫院乳癌患者之萘及雌性激素蛋白質胼合物背景值與年齡之相關性 53 6-1-3 彰化基督教醫院乳癌患者之雌激素及萘醌類蛋白質胼合物背景值與BMI之相關性 56 6-1-4 彰化基督教醫院乳癌患者及台南捐血中心之血清中萘及雌性激素醌類蛋白質胼合物背景值比較 59 6-1-5 彰化基督教醫院乳癌患者之萘及雌性激素蛋白質胼合物背景值與SNP之相關性 63 6-2 乳癌患者體內雌性激素血清白蛋白之蛋白質胼合物與健康人之比較 69 第七章 結論與建議 71 7-1結論 71 7-2建議 72 參考文獻 74 附錄A 84 萘醌類化物與蛋白質胼合物之定性及定量 84 雌性激素醌類化物與蛋白質胼合物之定性及定量分析 90zh_TW
dc.language.isozh_TWen_US
dc.publisher環境工程學系所zh_TW
dc.relation.urihttp://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1607201217262700en_US
dc.subject生物指標zh_TW
dc.subjectProtein adducten_US
dc.subject雌性激素zh_TW
dc.subjectzh_TW
dc.subjectBomarkeren_US
dc.subjectEstrogenen_US
dc.subjectQuinoneen_US
dc.title運用蛋白質胼合物作為生物指標探討乳癌風險因子與體內雌性激素與萘苯醌累積劑量之相關性分析zh_TW
dc.titleAssociations of the risk factors of breast cancer with cumulative body burden of estrogen and naphthalene quinones using protein adducts as biomarkersen_US
dc.typeThesis and Dissertationzh_TW
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