Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/60294
標題: Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
作者: Yao, Ya-Li
Yang, Wen-Ming
關鍵字: quality-control autophagy
urea cycle enzymes
reversible acetylation
nuclear-localization
calorie restriction
lysine acetylation
sirt
proteins
beta-catenin
cell-cycle
mitochondrial sirtuins
摘要: Acetylation of lysines is a prominent form of modification in mammalian proteins. Deacetylation of proteins is catalyzed by histone deacetylases, traditionally named after their role in histone deacetylation, transcriptional modulation, and epigenetic regulation. Despite the link between histone deacetylases and chromatin structure, some of the histone deacetylases reside in various compartments in the cytoplasm. Here, we review how these cytoplasmic histone deacetylases are regulated, the identification of nonhistone substrates, and the functional implications of their nondeacetylase enzymatic activities.
URI: http://hdl.handle.net/11455/60294
ISSN: 1110-7243
Appears in Collections:分子生物學研究所

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