Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/60453
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dc.contributor.authorWei, Y.K.en_US
dc.contributor.author賴建成zh_TW
dc.contributor.authorChen, Y.H.en_US
dc.contributor.authorLi, L.Y.en_US
dc.contributor.authorLang, J.Y.en_US
dc.contributor.authorYeh, S.P.en_US
dc.contributor.authorShi, B.en_US
dc.contributor.authorYang, C.C.en_US
dc.contributor.authorYang, J.Y.en_US
dc.contributor.authorLin, C.Y.en_US
dc.contributor.authorLai, C.C.en_US
dc.contributor.authorHung, M.C.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-09T05:56:31Z-
dc.date.available2014-06-09T05:56:31Z-
dc.identifier.issn1465-7392zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/60453-
dc.description.abstractEnhancer of zeste homologue 2 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and catalyses the trimethylation of histone H3 on Lys 27 (H3K27), which represses gene transcription. EZH2 enhances cancer-cell invasiveness and regulates stem cell differentiation. Here, we demonstrate that EZH2 can be phosphorylated at Thr 487 through activation of cyclin-dependent kinase 1 (CDK1). The phosphorylation of EZH2 at Thr 487 disrupted EZH2 binding with the other PRC2 components SUZ12 and EED, and thereby inhibited EZH2 methyltransferase activity, resulting in inhibition of cancer-cell invasion. In human mesenchymal stem cells, activation of CDK1 promoted mesenchymal stem cell differentiation into osteoblasts through phosphorylation of EZH2 at Thr 487. These findings define a signalling link between CDK1 and EZH2 that may have an important role in diverse biological processes, including cancer-cell invasion and osteogenic differentiation of mesenchymal stem cells.en_US
dc.language.isoen_USzh_TW
dc.relationNature Cell Biologyen_US
dc.relation.ispartofseriesNature Cell Biology, Volume 13, Issue 1, Page(s) 87-U211.en_US
dc.relation.urihttp://dx.doi.org/10.1038/ncb2139en_US
dc.subjectcyclin-dependent kinasesen_US
dc.subjectdevelopmental regulatorsen_US
dc.subjecthistone h3en_US
dc.subjectpolycomben_US
dc.subjectbreasten_US
dc.subjectcanceren_US
dc.subjectproliferationen_US
dc.subjectlysine-27en_US
dc.subjectprostateen_US
dc.subjectreceptoren_US
dc.titleCDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1038/ncb2139zh_TW
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