請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/61996
標題: Anti-angiogenic effects and mechanisms of polysaccharides from Antrodia cinnamomea with different molecular weights
作者: Yang, C.M.
胡淼琳
Zhou, Y.J.
Wang, R.J.
Hu, M.L.
關鍵字: Angiogenesis
Antrodia cinnamomea
Immunomodulation
Polysaccharides
Vascular endothelial growth factor
reishi polysaccharides
interleukin-12
camphorata
mushrooms
antitumor
cells
extract
tumors
期刊/報告no:: Journal of Ethnopharmacology, Volume 123, Issue 3, Page(s) 407-412.
摘要: Ethnopharmacological relevance: Antrodia cinnamomea is a popular medicinal mushroom in Taiwan that has been widely used for treatment of various cancers and liver diseases. Aim of the study:This study aimed to investigate the immunomodulatory effect on angiogenesis of polysaccharides from mycelia of Antrodia cinnamomea (PMAC). Materials and methods: PMAC were extracted in boiling water, precipitated with 95% ethanol, and separated into four different molecular weights (<5, 5-30, 30-100, >100 kDa). Tube formation and chorioallantoic membrane (CAM) assay were used to determine the in vitro and ex vivo anti-angiogenic effects. Results: Only the PMAC-mononuclear cells (MNCs)-conditioned medium (CM) with MW > 100 kDa significantly and concentration-dependently decreased the secretion of vascular endothelial growth factor in human leukemia cells and inhibited the matrigel tube formation in human umbilical vein endothelial cells. Similarly only the PMAC-MNC-CM with MW > 100 kDa significantly and concentration-dependently increased the levels of interleukin (IL)-12 and interferon-gamma (IFN-gamma). In addition, the ex vivo CAM assay revealed that only the PMAC with MW > 100 kDa significantly and dose-dependently inhibited neovascularization. Conclusions: PMAC with MW > 100 kDa are anti-angiogenic in vitro and ex vivo, and the effects are likely through immunomodulation. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/61996
ISSN: 0378-8741
文章連結: http://dx.doi.org/10.1016/j.jep.2009.03.034
顯示於類別:食品暨應用生物科技學系

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