請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/61997
標題: Antiproliferative and antimetastatic effects of the ethanolic extract of Phellinus igniarius (Linnearus : Fries) Quelet
作者: Song, T.Y.
胡淼琳
Lin, H.C.
Yang, N.C.
Hu, M.L.
關鍵字: antiproliferation
antimetastasis
Phellinus igniarius
synergy
oxaliplatin
5-flurouracil
endothelial growth-factor
cells in-vitro
hepatocellular-carcinoma
caffeic acid
cancer-cells
angiogenesis
metastasis
expression
flavonoids
permeability
期刊/報告no:: Journal of Ethnopharmacology, Volume 115, Issue 1, Page(s) 50-56.
摘要: Aim of this study: Phellinus igniarius (Linnearus: Fries) Quelet (Phellinus igniarius) has been used in oriental countries for treatment of various diseases including cancer. However, it is unclear how Phellinus igniarius exerts anticancer effects. Materials and methods: In this study the ethanolic extract from the fruiting body of Phellinus igniarius (EEPI) was used to evaluate the antiproliferative and antimetastatic effects in human hepatocarcinoma SK-Hep-1 cells and rat heart vascular endothelial cells (RHE cells). Results: We found that EEPI inhibited the proliferation of both cell lines in a dose-dependent manner, and the IC50 values at 48 h were 72 and 103 mu g/ml for SK-Hep-1 cells and RHE cells, respectively. EEPI at non- or sub-cytotoxic concentrations (25-100 mu g/ml) markedly inhibited the migration and invasion of SK-Hep-1 cells. EEPI added at 25 mu g/ml significantly decreased the secretion of matrix metalloproteinase-2 (MMP-2) (49%, p < 0.01) and vascular endothelial growth factor (VEGF) (13%, p < 0.05) in SK-Hep-1 cells. EEPI at 25 mu g/ml completely inhibited matrigel-induced tube formation in RHE cells. Importantly, EEPI (25 or 50 mu g/ml) in combination with oxaliplatin (Oxa) or 5-flurouracil (5-FU) synergistically inhibited the proliferation of SK-Hep-1 cells. Conclusion: These results demonstrate the antiproliferative and antimetastatic effects of EEPI in vitro and the potential of EEPI as an adjuvant for chemotherapy. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
URI: http://hdl.handle.net/11455/61997
ISSN: 0378-8741
文章連結: http://dx.doi.org/10.1016/j.jep.2007.09.001
顯示於類別:食品暨應用生物科技學系

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