Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/62004
標題: Dietary selenium and vitamin E affect adrenal and brain dehydroepiandrosterone levels in young rats
作者: Hu, M.L.
胡淼琳
Ng, H.P.
關鍵字: vitamin E
selenium
dehydroepiandrosterone
adrenal
rats
lipid-peroxidation
glutathione-peroxidase
alpha-tocopherol
thyroid-hormone
dhea
sulfate
liver
期刊/報告no:: Journal of Nutritional Biochemistry, Volume 9, Issue 6, Page(s) 339-343.
摘要: This study tested the hypothesis that dietary selenium (Se) and vitamin E can affect dehydroepiandrosterone (DHEA) levels in the adrenal glands and the brain in young rats. Male Sprague-Dawley rats (4-weeks-old) were fed Se-deficient or Se-supplemented (0.2 mg Se/kg) diets containing 0, 30, or 200 mg dl-alpha-tocopheryl acetate/kg diet for 6 weeks. The results showed that neither dietary Se nor vitamin E affected body weight or relative adrenal weights (expressed as per 100 g body weight). As expected, serum glutathione peroxidase activity in Se-deficient rats was low, only approximately 6% of that in Se-supplemented rats. Dietary vitamin E markedly (P < 0.001) and dose-dependently inhibited peroxide-induced hepatic lipid peroxidation, suggesting that vitamin E content in rat tissues reflected those in the diets. The adrenal DHEA levels were significantly decreased by both Se and vitamin E deficiency. Brain DHEA levels were significantly decreased by vitamin E deficiency by not by Se deficiency. Supplementation with 200 mg dl-alpha-tocopheryl acetate/kg diet did not increase DHEA levels in either the adrenal glands or the brain, and there were no interactions on DHEA levels between the two dietary factors. Thus, this study in young rats demonstrates that dietary antioxidants affect adrenal gland and brain DHEA levels and that vitamin E appears to play a more importance role than does Se. (J. Nutr Biochem. 9:339-343, 1998) (C) Elsevier Science Inc. 1998.
URI: http://hdl.handle.net/11455/62004
ISSN: 0955-2863
文章連結: http://dx.doi.org/10.1016/s0955-2863(98)00024-2
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