請用此 Handle URI 來引用此文件: http://hdl.handle.net/11455/62042
標題: Green tea catechin inhibits ephrin-A1-mediated cell migration and angiogenesis of human umbilical vein endothelial cells
作者: Tang, F.Y.
蔣恩沛
Chiang, E.P.I.
Shih, C.J.
關鍵字: epigallocatechin gallate
ephrin-A1
EphA2
PI-3K
ERK-1/2
cell
migration
angiogenesis
receptor tyrosine kinase
eph receptors
cardiovascular development
vascular development
growth-factors
cancer
ligands
phosphorylation
suppression
ephrin-b2
期刊/報告no:: Journal of Nutritional Biochemistry, Volume 18, Issue 6, Page(s) 391-399.
摘要: Angiogenesis, the formation of new blood vessels from preexisting capillaries, is essential for tumor progression and metastasis. During tumor neovascularization, vascular endothelial growth factor and ephrin (Eph) families emerge as critical mediators of angiogenesis. The green tea catechin epigallocatechin gallate (EGCG), a tyrosine kinase inhibitor, has been demonstrated in previous studies to be an effective anti angiogenesis agent. However, the inhibitory effect of green tea catechins on ephrin-A1-mediated tumor angiogenesis has not been demonstrated yet. Thus, in this study, we investigated the molecular mechanism of ephrin-A1-mediated cell migration and angiogenesis, as well as the inhibitory effects of EGCG. Here we show that ephrin-A1 mediates endothelial cell migration and regulates vascular remodeling in tumor neovascularization in vitro. We also demonstrated that ephrin-A1-mediated cell migration required the activation of extracellular-regulated kinase (ERK-1/2) but not of phosphatidylinositol-3-kinase. The green tea catechin EGCG inhibited ephrin-A1-mediated endothelial cell migration, as well as tumor angiogenesis, in a dose-dependent manner. Furthermore, EGCG inhibited the ephrin-A1-mediated phosphorylation of EphA2 and EPK-1/2. Taken together, these data indicated that activation of ERK-1/2 plays an essential role in ephrin-A1-mediated cell migration. EGCG inhibited ephrin-A1-mediated endothelial migration and angiogenesis. It suggests a novel antiangiogenesis application of EGCG in cancer chemoprevention. (C) 2007 Elsevier Inc. All rights reserved.
URI: http://hdl.handle.net/11455/62042
ISSN: 0955-2863
文章連結: http://dx.doi.org/10.1016/j.jnutbio.2006.07.004
顯示於類別:食品暨應用生物科技學系

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